Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases

Informazioni relative al progetto

NANOFOL

ID dell’accordo di sovvenzione: 228827

Progetto chiuso

Data di avvio 1 Dicembre 2009

Data di completamento 30 Novembre 2013

Finanziato da

• Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Costo totale € 6 635 409,43

Contributo UE € 5 149 874,00

Coordinato da

UNIVERSIDADE DO MINHO
Portugal

Obiettivo

NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies. NANOFOL will achieve all that by fulfilling the following objectives: •Design , development and production of nanobiodevices (FBN) targeting directly effector cells •Proof of concept in vitro and in vivo of a folate based nanodevice targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept in vitro and in vivo of a nanodevice containing a bispecific antibody (against folate receptor and another macrophage marker) targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept of FBN delivery therapeutic agents (by small interfering ribonucleic acid molecules (siRNA) or lipophylic molecules) targeting inflammatory signaling pathways •In vitro and in vivo testing of cellular toxicity caused by the novel nanobiodevices in cells other than activated macrophages •Design of models that will enable to minimize animal experimentation. •Development of a strategy to assess potential risks in order to ensure nanobiodevice safe delivery. NANOFOL has adopted a specific risk strategy to attain objectives in a step by step approach allowing improving gradually the concept (specificity, stability, side effects efficacy) from the lower to the higher risky solutions ensuring reduced experimental animal testing and high human safety. The NANOFOL project will combine expertise in nanotechnologies, biology, chemistry, materials science, biotechnology, engineering, risk analysis, medical and pharmaceutical sciences.

Campo scientifico

• medical and health sciences › clinical medicine › rheumatology
• medical and health sciences › health sciences › inflammatory diseases
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases › arteriosclerosis
• engineering and technology › nanotechnology

Programma(i)

• FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Argomento(i)

• NMP-2008-4.0-1 - Development of nanotechnology-based systems for diagnosis and/or therapy for diabetes, muscolo-skeletal or inflammatory diseases (in coordination with Theme HEALTH)

Invito a presentare proposte

FP7-NMP-2008-LARGE-2
Vedi altri progetti per questo bando

Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

UNIVERSIDADE DO MINHO

• Contributo UE: € 1 054 530,00
• Indirizzo: LARGO DO PACO ; 4704 553 Braga ; Portogallo
• Regione: Continente › Norte › Cávado
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Vasco Manuel Pinto Texeira (Prof.)
• Costo totale: Nessun dato

Partecipanti (13)

SUAN FARMA S.A.

Spagna

• Contributo UE: € 125 572,55
• Indirizzo: Einstein 8 ; 28108 Alcobendas
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Ion Arocena Velez (Mr.)
• Costo totale: Nessun dato

TECHNISCHE UNIVERSITAET GRAZ

Partecipazione conclusa

Austria

• Contributo UE: € 304 036,84
• Indirizzo: RECHBAUERSTRASSE 12 ; 8010 Graz
• Regione: Südösterreich › Steiermark › Graz
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Georg Guebitz (Prof.)
• Costo totale: Nessun dato

NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Paesi Bassi

• Contributo UE: € 453 858,53
• Indirizzo: ANNA VAN BUERENPLEIN 1 ; 2595 DA Den Haag
• Regione: West-Nederland › Zuid-Holland › Agglomeratie ’s-Gravenhage
• Tipo di attività: Research Organisations
• Contatto amministrativo: Herman Lenting (Dr.)
• Costo totale: Nessun dato

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC

Portogallo

• Contributo UE: € 314 437,56
• Indirizzo: RUA ALFREDO ALLEN 208 ; 4200 135 Porto
• Regione: Continente › Norte › Área Metropolitana do Porto
• Tipo di attività: Research Organisations
• Contatto amministrativo: Claudia Ferreira (Dr.)
• Costo totale: Nessun dato

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Francia

• Contributo UE: € 522 780,00
• Indirizzo: RUE DE TOLBIAC 101 ; 75654 Paris
• Regione: Ile-de-France › Ile-de-France › Paris
• Tipo di attività: Research Organisations
• Contatto amministrativo: Tiphaine Guida (Mrs.)
• Costo totale: Nessun dato

MEDIZINISCHE UNIVERSITAET WIEN

Austria

• Contributo UE: € 452 432,55
• Indirizzo: SPITALGASSE 23 ; 1090 Wien
• Regione: Ostösterreich › Wien › Wien
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Hannes Stockinger (Prof.)
• Costo totale: Nessun dato

UNIVERSITATEA AUREL VLAICU DIN ARAD

Romania

• Contributo UE: € 285 175,25
• Indirizzo: BULEVARD REVOLUTIEI 77 ; 310130 Arad
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Ramona Lile (Prof.)
• Costo totale: Nessun dato

SYNOVO GMBH

Germania

• Contributo UE: € 368 373,90
• Indirizzo: Paul Ehrlich Str 15 ; 72076 Tuebingen
• Regione: Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Michael Burnet (Dr.)
• Costo totale: Nessun dato

INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES - INERIS

Francia

• Contributo UE: € 468 319,00
• Indirizzo: PARC TECHNOLOGIQUE ALATA ; 60550 Verneuil En Halatte
• Regione: Hauts-de-France › Picardie › Oise
• Tipo di attività: Research Organisations
• Contatto amministrativo: Lydia Boutigny (Ms.)
• Costo totale: Nessun dato

EXBIO PRAHA AS

Cechia

• Contributo UE: € 418 175,60
• Indirizzo: Nad Safinou II, 366 ; 25242 VESTEC
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Stanislav Lancouch
• Costo totale: Nessun dato

AYMING

Francia

• Contributo UE: € 213 007,00
• Indirizzo: RUE CHAPTAL 114 ; 92300 Levallois-Perret
• Regione: Ile-de-France › Ile-de-France › Hauts-de-Seine
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Maud Bossard (Ms.)
• Costo totale: Nessun dato

Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda.

Partecipazione conclusa

Portogallo

• Contributo UE: € 21 767,53
• Indirizzo: Av. da Republica, Quinta do Marques, Estacao Agronomica Nacional IBET/ITQB, Lab.7.14 ; 2780-157 Oeiras
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Costo totale: Nessun dato

UNIVERSITAET FUER BODENKULTUR WIEN

Austria

• Contributo UE: € 147 407,69
• Indirizzo: GREGOR MENDEL STRASSE 33 ; 1180 Wien
• Regione: Ostösterreich › Wien › Wien
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Georg Guebitz (Prof.)
• Costo totale: Nessun dato