Traditional Chinese Medicine in the Post-genomic era: identifying lead therapeutic compounds against cancer

Projektinformationen

TCMCANCER

ID Finanzhilfevereinbarung: 230232

Projekt abgeschlossen

Startdatum 1 März 2009

Enddatum 28 Februar 2013

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 237 600,00

EU-Beitrag € 237 600,00

Koordiniert durch

LUXEMBOURG INSTITUTE OF HEALTH
Luxembourg

Ziel

This application aims at identifying and characterizing a set of lead therapeutic compounds against cancer (breast, lung and brain), based on current knowledge from Traditional Chinese Medicine (TCM). TCM has a very long tradition in the prevention and treatment of a variety of diseases yet, in contrast to target-oriented Western medicine, TCM uses a holistic and synergistic approach, which can be very effective for complex medical problems. However, the exact composition of the compounds that exert the therapeutic effect is not known. As there is little understanding about the mechanisms of action of many TCM therapies, modern and multidisciplinary Biotech research (functional genomics/ systems biology) should be applied on appropriate and highly defined cancer models. The presented project will focus on the isolation and characterization of chemical compounds from TCM that show anti-tumoral efficacy. From a library of therapeutic compounds available, a set of lead therapeutic substances will be identified using high throughput screening technologies in appropriate preclinical cancer models. Moreover, their mechanism of action will be further studied using genome wide analyses. Finally, their therapeutic efficacy will be tested in appropriate animal models.

Wissenschaftliches Gebiet

• medical and health sciences › clinical medicine › oncology
• natural sciences › biological sciences › genetics › genomes

Schlüsselbegriffe

• Health sciences
• animal models
• herbal compounds
• high-throughput screen
• spheroids
• transcript analyis
• tumour cell lines

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-IRSES-2008 - Marie Curie Action "International Research Staff Exchange Scheme"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-IRSES-2008
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IRSES - International research staff exchange scheme (IRSES)

Koordinator

LUXEMBOURG INSTITUTE OF HEALTH

Kontakt Verwaltung

Daniel Cardao (Mr.)

• EU-Beitrag: € 237 600,00
• Adresse: 1A RUE RUE THOMAS EDISON ; 1445 Strassen ; Luxemburg
• Region: Luxembourg › Luxembourg › Luxembourg
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten