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Contenuto archiviato il 2024-05-27

The role of lipid membranes in dengue virus assembly

Obiettivo

Viral hemorrhagic fever is a serious health threat mostly caused by the Dengue Virus (DV), which infects 50 to 100 million people worldwide yearly. Aedes spp. mosquitoes, the disease vectors endemic to tropical and subtropical regions, are spreading to temperate regions. A. aegypti, the main vector, is now found in Madeira, Portugal, and A. albopictus, a less frequent albeit potential vector, is present in several European countries. Conditions for a possible dengue outbreak in Europe are now set, only being necessary the mosquitoes to enter in contact with human viral carriers, as recently occurred in the A. albopictus promoted Chikungunya fever 2007 outbreak in Italy. DV infection is therefore a potential clinical problem for Europe, as stated in the EU FP7 Emerging Epidemics program (http://ec.europa.eu/research/health/). Once infected, no specific treatment is available, partially due to the lack of detailed information on the molecular mechanisms of viral assembly. The project intends to fill that gap by studying the viral assembly capsid protein, in biologically relevant conditions, using lipid bilayers mimicking biological membranes and intracellular lipid droplets isolated from hepatic cell lines. The project gathers the complementary expertise of two teams, each having a distinct yet synergistic role. Prof. Da Poian, from the Medical Biochemistry Institute, Federal University of Rio de Janeiro, Brazil, has expertise in cell and molecular biology, NMR and calorimetry studies applied to DV proteins. Prof. Santos, from the Institute of Molecular Medicine, Lisbon, Portugal, is skilled in light scattering spectroscopy and atomic force microscopy applied to lipid bilayers interaction with viral proteins. Thus the project assembles an eclectic gathering of complementary expertise to study the role of lipid membranes in dengue viral assembly. Following this approach, it is expected to open a gateway to the future development of capsid assembly-targeted therapies.

Invito a presentare proposte

FP7-PEOPLE-IOF-2008
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Coordinatore

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Contributo UE
€ 137 311,75
Indirizzo
AVENIDA PROF EGAS MONIZ
1649 028 Lisboa
Portogallo

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Regione
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Tipo di attività
Research Organisations
Contatto amministrativo
Margarida Pinto Gago (Dr.)
Collegamenti
Costo totale
Nessun dato