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Novel multifunctional cyclodextrin-based nanocarriers for drug encapsulation and delivery as a strategy to overcome current therapeutic drawbacks

Objective

There is a high demand for the development of new drug delivery strategies to combat major diseases in our society, particularly cancer. Current treatments are based on high efficacy drugs, however their non-selective uptake by both normal and tumor cells as well as the development of multidrug resistance (MDR), constitute major hurdles. Resistance is also associated with the use of nucleoside analogues as anticancer drugs in vivo. Photodynamic therapy (PDT), aims at selectively killing neoplastic lesions by the combined action of a photosensitizer and visible light. Passive targeting, involving enhanced permeability and retention effect, allows the accumulation of drugs on tumor sites, and concomitant active targeting with suitable functionalities, constitute properties currently associated with polymeric delivery systems. Cyclodextrins (CDs) are biocompatible and biodegradable oligosaccharide nanocages, known to improve the solubility, stability and bioavailability of drugs. Scattered literature reports incidents that CDs may constitute potential means to overcome certain forms of MDR, or to effectively deliver photosensitizing anticancer drugs preserving their photodynamic properties. This network, highly specialized in CD chemistry, photochemistry, in vitro drug evaluation and in vivo applications, proposes to synthesize diverse families of new CD derivatives to build a platform of CD-based drug delivery nanosystems with a variety of architectures. These new generation nanocarriers, encompassing many cavities in a nm-sized vehicle, will possess high drug loading capacity, improved permeability and retention effect, enhanced targeting and complete biocompatibility. Their mode of action will be assessed in vitro and in vivo. These goals will be achieved via a strong training program of ESRs and ERs in a highly collaborating, multidisciplinary and application oriented program, with full participation of an SME partner, a leader in CD applications.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/multidrug resistance

Call for proposal

FP7-PEOPLE-ITN-2008
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""
Address
End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi
Greece
Activity type
Research Organisations
EU contribution
€ 411 432
Administrative Contact
Styliani Martaki (Ms.)

Participants (8)

UNIVERSIDAD DE CASTILLA - LA MANCHA
Spain
EU contribution
€ 324 040
Address
Calle Altagracia 50
13071 Ciudad Real
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Llanos Carrion-Varela (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 348 297
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Michèle Saumon (Dr.)
HASKOLI ISLANDS
Iceland
EU contribution
€ 249 269
Address
Saemundargotu 2
101 Reykjavik
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sigurdur J. Hafsteinsson (Mr.)
UNIVERSITA DEGLI STUDI DI CATANIA
Italy
EU contribution
€ 299 649
Address
Piazza Universita 2
95131 Catania
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Clara Pluchino (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 211 603
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Giancarlo Seconi (Dr.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 218 583
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ludde Edgren (Dr.)
UNIVERSIDAD DE ALMERIA
Spain
EU contribution
€ 195 917
Address
Carretera Sacramento Canada
04120 Almeria
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Antonio Miguel Posadas Chinchilla (Prof.)
CYCLOLAB CIKLODEXTRIN KUTATO-FEJLES
Hungary
EU contribution
€ 156 757
Address
Illatos 7
1097 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Erzsebet Szilagyi (Dr.)