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Joint training and research on Hedhehog-Gli signalling and its pharmacological modulation for regenerative medicine

Ziel

Debilitating degenerative diseases such as non-healing wounds and neurodegeneration do not yet have a cure. They represent a huge unmet medical need worldwide, especially in the aging European population. To reduce the incidence and improve recovery from such ephitelial diseases there is an major need to understand molecular signaling in order to promote stem cell behavior and enhance regeneration and healing. The key objectives of the HEALING network are 1) to train researchers in the fields of molecular signaling, developmental genetics, stem cell biology and small molecule chemistry; 2) to elucidate the mechanisms regulating one of the most promising pathways, Hedgehog-Gli (Hh-Gli) signaling; 3) to manipulate it by the development of specific small molecule agonists for future therapeutic use. Specifically, our research will (a) analyze the basic molecular mechanisms of Hh-Gli signaling in two model organisms and in human cells using leading technologies. In particular, (b) address the mechanisms that ensure controlled Hh-Gli function during skin wound healing and brain repair. (c) develop new small molecule Hh-Gli agonists for use as tools to be used as future therapeutics to enhance wound healing, regeneration and repair in a controlled manner. This network consists of 7 leading academic and research institutions, and 2 biotech companies from 8 European countries. It strengthens existing scientific collaboration, provides complementary expertise and brings together a critical mass for training and research. Additionally, it includes experts from Europe, Canada and Singapore, notably a pioneer in Hh-Gli signaling. HEALING will greatly enhance the training of the next generation of leading scientists in Hh-Gli signaling, stem cells and regenerative medicine. Thus, it will increase the competitiveness of highly skilled staff and of the European biotech industry, which has just recently discovered the role of Hh-Gli signaling in human disease and lags behind the US

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-ITN-2008
Andere Projekte für diesen Aufruf anzeigen

Koordinator

UNIVERSITE DE GENEVE
Adresse
Rue Du General Dufour 24
1211 Geneve
Schweiz
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 1 081 048
Kontakt Verwaltung
Ariel Ruiz I Altaba (Prof.)

Beteiligte (8)

ANALYTICON DISCOVERY GMBH
Deutschland
EU-Beitrag
€ 400 692
Adresse
Hermannswerder Haus 17
14473 Potsdam
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Jochen Gatter (Mr.)
CANCER RESEARCH UK LBG
United Kingdom
EU-Beitrag
€ 401 263
Adresse
St John Street 407 Angel Building
EC1V 4AD London
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Robina Ibanda (Ms.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spanien
EU-Beitrag
€ 601 736
Adresse
Calle Serrano 117
28006 Madrid
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Carlos Manuel Abad Ruiz (Mr.)
IDRYMA TECHNOLOGIAS KAI EREVNAS
Griechenland
EU-Beitrag
€ 206 702
Adresse
N Plastira Str 100
70013 Irakleio
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Zinovia Papatheodorou (Ms.)
KAROLINSKA INSTITUTET
Schweden
EU-Beitrag
€ 419 841
Adresse
Nobels Vag 5
17177 Stockholm
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Ingwar Lennerfors (Mr.)
PARIS-LODRON-UNIVERSITAT SALZBURG
Österreich
EU-Beitrag
€ 200 345
Adresse
Kapitelgasse 4-6
5020 Salzburg
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Fritz Aberger (Prof.)
Phistem Sàrl

Beteiligung beendet

Schweiz
Adresse
Avenue De La Roseraie 64
1211 Geneva
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Frédéric Lajunais (Dr.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italien
EU-Beitrag
€ 421 937
Adresse
Piazzale Aldo Moro 5
00185 Roma
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Giancarlo Bertea (Mr.)