Final Report Summary - HSF-1 LONGEVITY/PROT (Identifying the Heat Shock Factor -1 <br/>Longevity Assurance and Proteostasis Co-regulators and Target genes)
Our findings have critical importance for the evaluation of IIS reduction as a novel therapeutic approach aimed to treated late-onset disorders such as Alzheimer's disease by selective manipulation of the aging process. It highlighted the roles of inter-tissue communication in the regulation of protein homeostasis and identified specific genes which play roles in this mechanism. Further research will be required to develop this therapeutic strategy for the benefit of patients who suffer from neurodegenerative maladies and their families.