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New methods for the divergent synthesis of non-natural amino acids under aqueous conditions

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The ultimate goal of this research is to develop reliable chemical methodology that can allow the modification of specific amino acid side-chains in peptides in a highly divergent manner providing access to a wide variety of "mutants" containing non-natural amino acids at a specific site from a single precursor. The approach will involve the preparation of a variety of boron-containing amino acids, either as precursors, or by derivatisation of existing amino acid residues in peptide chains, and then use of the Suzuki reaction to introduce the desired non-natural side-chains.

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FP6-2002-MOBILITY-5
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EIF - Marie Curie actions-Intra-European Fellowships

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THE UNIVERSITY OF SHEFFIELD
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