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New methods for the divergent synthesis of non-natural amino acids under aqueous conditions

Obiettivo

The ultimate goal of this research is to develop reliable chemical methodology that can allow the modification of specific amino acid side-chains in peptides in a highly divergent manner providing access to a wide variety of "mutants" containing non-natural amino acids at a specific site from a single precursor. The approach will involve the preparation of a variety of boron-containing amino acids, either as precursors, or by derivatisation of existing amino acid residues in peptide chains, and then use of the Suzuki reaction to introduce the desired non-natural side-chains.

Campo scientifico (EuroSciVoc)

Parole chiave

Argomento(i)

Invito a presentare proposte

FP6-2002-MOBILITY-5
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Meccanismo di finanziamento

EIF - Marie Curie actions-Intra-European Fellowships

Coordinatore

THE UNIVERSITY OF SHEFFIELD
Contributo UE
Nessun dato
Indirizzo


Regno Unito
Costo totale
Nessun dato