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European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs

Objectif

The past decade has seen tremendous progress in our understanding of homeostatic regulators controlling energy balance. Insights from human and murine genetics have illuminated multiples pathways within the hypothalamus, brainstem and higher brain regions that play a key role in the control of food intake, whilst physiological studies focusing on the gastrointestinal tract have revealed a panoply of hormones that are secreted in response to or in anticipation of food intake and act centrally to regulate appetite. EurOCHIP brings together world leaders specializing in both areas in order to explore the interaction between the periphery and the brain in the control of energy homeostasis. Our programme of research will comprise four interdependent work-packages: i) characterising the interaction of gastrointestinal hormones with the hypothalamus and brainstem, with the aim of identifying novel molecules and pathways that mediate food intake; ii) using imaging techniques and behavioural phenotyping to explore the response of brain areas involved in higher cognitive and affective functions to these gastrointestinal hormones; iii) harnessing the power of human genetics to determine the role of sequence variation in and around newly identified candidate genes in appetitive behaviour and response to dietary interventions, focusing in particular on childhood obesity and iv) determining the effects of specific dietary interventions on gastrointestinal hormone secretion and using pharmacological studies in humans to mimic the hormonal milieu seen after a meal or bariatric surgery.

Appel à propositions

FP7-HEALTH-2009-single-stage
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Coordinateur

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Adresse
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Keith Cann (Mr.)
Contribution de l’UE
€ 546 666,11

Participants (8)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Contribution de l’UE
€ 387 440
Adresse
South Kensington Campus Exhibition Road
SW7 2AZ London

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Mike Robinson (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Contribution de l’UE
€ 387 440
Adresse
Rue Michel Ange 3
75794 Paris

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Type d’activité
Research Organisations
Contact administratif
Gilles Pulvermuller (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Contribution de l’UE
€ 387 560
Adresse
Rue De Tolbiac 101
75654 Paris

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Type d’activité
Research Organisations
Contact administratif
Lyddie Laaland (Ms.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Allemagne
Contribution de l’UE
€ 387 640
Adresse
Kerpener Strasse 62
50937 Koeln

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Jutta Landvogt (Ms.)
DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE

Participation terminée

Allemagne
Contribution de l’UE
€ 172 289,14
Adresse
Arthur-scheunert-allee 114-116
14558 Nuthetal

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Type d’activité
Research Organisations
Contact administratif
Judith Schaefer (Dr.)
GOETEBORGS UNIVERSITET
Suède
Contribution de l’UE
€ 387 400
Adresse
Vasaparken
405 30 Goeteborg

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Margareta Ahlqwist (Dr.)
EUROQUALITY SARL
France
Contribution de l’UE
€ 128 345
Adresse
Rue De L Isly 8
75008 Paris 08

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Marc Ponsar (Mr.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Allemagne
Contribution de l’UE
€ 215 215,75
Adresse
Ingolstadter Landstrasse 1
85764 Neuherberg

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Type d’activité
Research Organisations
Contact administratif
Juergen Ertel (Dr.)