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Enhanced Protective Immunity Against Filariasis

Objective

Filarial infections remain a major public health problem in West and Central Africa. Three filarial species are involved: Onchocerca volvulus (onchocerciasis or river blindness); Wuchereria bancrofti (lymphatic filariasis); and Loa loa (the eye worm). Treatment of onchocerciasis with ivermectin has been successful in many situations but emergence of drug resistance and risk of severe adverse reactions associated with L loa co-infections is restricting the implementation of mass treatment and consequently alternate approaches to control are required. Studies with animal models have identified the general mechanisms of protective immunity while human studies have drawn attention to immune regulatory processes that influence clinical presentations Together, these observation provide a basis for vaccine development. The next challenge is to identify target antigens and ensure appropriate formulation and delivery to promote protective responses and avoid any pathology. This project aims to: 1, use transciptomics and bioinformatics to identify the parasite molecules that are targets of protective immunity and that may influence the regulation of such responses; and 2, microarray technologies and bioinformatics to determine the pathways that lead to expression of protective immunity. Cohorts of onchocerciasis patients who have received treatment with ivermectin or tetracycline, or are co infected with either W bancrofti or L loa provide both input to the pathway studies and a means of validation of the computer assimilations. Confirmation of the mechanisms and targets of protective immunity and validation of computer assimilations will also be investigated using the O ochengi-cattle model that also enables experimentation under natural challenge. Litomosoides sigmodontis in mice provides a robust and rapid validation of results obtained from computation relating to expression and regulation of protective responses and a primary system for screening vaccine candidates

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Coordinator

THE UNIVERSITY OF EDINBURGH
Address
Old College, South Bridge
EH8 9YL Edinburgh
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 449 784
Administrative Contact
Angela Noble (Ms.)

Participants (10)

Research Foundation in Tropical Diseases and Environment
Cameroon
EU contribution
€ 348 898
Address
University Street
474 Buea
Activity type
Research Organisations
Administrative Contact
Ayuk Peter Enyong (Dr.)
INSTITUT DE RECHERCHE AGRICOLE POUR LE DEVELOPPEMENT
Cameroon
EU contribution
€ 220 176
Address
Po Box
N/A Yaounde
Activity type
Research Organisations
Administrative Contact
Vincent Ngwang Tanya (Dr.)
KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY KUMASI
Ghana
EU contribution
€ 227 304
Address
Private Mail Bag, University Post Office
ASH Kumasi
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sabastian Kankam (Mr.)
INSTITUT NATIONAL D'HYGIENE
Togo
EU contribution
€ 215 424
Address
Rue Nangbeto
1396 Lome
Activity type
Research Organisations
Administrative Contact
Meba Banla (Prof.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 610 912
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Suzanne Halpin (Ms.)
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 559 670
Address
Venusberg-campus 1
53127 Bonn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Becker (Ms.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 478 516
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Soboslay (Prof.)
MUSEUM NATIONAL D'HISTOIRE NATURELLE
France
EU contribution
€ 489 316
Address
Rue Cuvier 57
75005 Paris
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Coralie Martin (Dr.)
Fios Genomics Limited
United Kingdom
EU contribution
€ 400 000
Address
Buchanan Street 166
G1 2LS Glasgow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gary Rubin (Dr.)
UNIVERSITY OF GLASGOW
United Kingdom
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joe Galloway (Mr.)