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A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure

Objective

Heart failure is common in Europe and its prevalence is increasing as our population ages. Despite major improvements in care since the early 90s, it is still related to a poor prognosis, an impaired quality of life and high health care costs. Many new therapies have failed to improve outcome further. One obvious reason is that the response to treatment is not homogenous. Treatment may need to be tailored to the individual patient. BIOSTAT-CHF aims to identify patients with a poor outcome, despite currently recommended therapy using information on demographics, gender, existing biomarkers, genetics and proteomics. Both genomic and proteomic analyses recently underwent major technical improvements, resulting in genome-wide analyses and detection of low abundance proteins. In BIOSTAT-CHF an index cohort of 2500 patients hospitalized with acute decompensated heart failure, will be recruited after initial stabilization. Treatment will be optimized according to the heart failure guidelines of the European Society of Cardiology with diuretics, ACE-inhibitors, betablockers and aldosterone antagonists. When patients are optimally treated, any change in symptoms and exercise tolerance will be evaluated. Patients will then be followed up for a mean of 18 months, and mortality and heart failure hospitalizations will be recorded. By using a systems biology approach, incorporating information from demographic, biomarker, genomic, proteomic, and the initial response to therapy, a risk prediction model will be designed, identifying patients with a poor outcome on currently recommended therapy. This model will then be validated in a real-life cohort of 2500 chronic heart failure patients. BIOSTAT-CHF will therefore be a major step towards personalized medicine. Identifying patients with a poor outcome on currently recommended therapy might lead to further development of targeted therapies, eventually leading to improvements in outcome for patients with heart failure in Europe

Field of science

  • /natural sciences/biological sciences/genetics and heredity
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/clinical medicine/cardiology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Address
Hanzeplein 1
9713 GZ Groningen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 345 849,15
Administrative Contact
Carla Hooijschuur (Ms.)

Participants (10)

UNIVERSITA DEGLI STUDI DI BRESCIA
Italy
EU contribution
€ 820 050
Address
Piazza Mercato 15
25121 Brescia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aldo Cuzzucoli (Dr.)
FONDATION TRANSPLANTATION
France
EU contribution
€ 489 855
Address
Rue De La Brot 4
21850 St Apollinaire
Activity type
Research Organisations
Administrative Contact
Stéphanie Grojean (Ms.)
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 489 999,60
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Efi Kafentzi (Ms.)
UNIVERSITY OF HULL
United Kingdom
EU contribution
€ 490 017,45
Address
Cottingham Road
HU6 7RX Hull
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wayne Sheedy (Mr.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 620 000,40
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Clementia.C.M. (Tineke) Kranendonk-Van Der Ploeg (Ms.)
UNIWERSYTET MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU
Poland
EU contribution
€ 489 999,60
Address
Ul Pasteura 1
50 367 Wroclaw
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Agnieszka Urbanska (Ms.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 950 262
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)
HELSE STAVANGER HF
Norway
EU contribution
€ 389 280
Address
Gerd Ragna Bloch Thorsens Gate 8
4011 Stavanger
Activity type
Other
Administrative Contact
Kenneth Dickstein (Prof.)
UNIVERSITY OF LEICESTER
United Kingdom
EU contribution
€ 2 939 250
Address
University Road
LE1 7RH Leicester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marie Adams (Ms.)
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 869 724,20
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Chim Lang (Prof.)