Obiettivo Heart failure is common in Europe and its prevalence is increasing as our population ages. Despite major improvements in care since the early 90s, it is still related to a poor prognosis, an impaired quality of life and high health care costs. Many new therapies have failed to improve outcome further. One obvious reason is that the response to treatment is not homogenous. Treatment may need to be tailored to the individual patient. BIOSTAT-CHF aims to identify patients with a poor outcome, despite currently recommended therapy using information on demographics, gender, existing biomarkers, genetics and proteomics. Both genomic and proteomic analyses recently underwent major technical improvements, resulting in genome-wide analyses and detection of low abundance proteins. In BIOSTAT-CHF an index cohort of 2500 patients hospitalized with acute decompensated heart failure, will be recruited after initial stabilization. Treatment will be optimized according to the heart failure guidelines of the European Society of Cardiology with diuretics, ACE-inhibitors, betablockers and aldosterone antagonists. When patients are optimally treated, any change in symptoms and exercise tolerance will be evaluated. Patients will then be followed up for a mean of 18 months, and mortality and heart failure hospitalizations will be recorded. By using a systems biology approach, incorporating information from demographic, biomarker, genomic, proteomic, and the initial response to therapy, a risk prediction model will be designed, identifying patients with a poor outcome on currently recommended therapy. This model will then be validated in a real-life cohort of 2500 chronic heart failure patients. BIOSTAT-CHF will therefore be a major step towards personalized medicine. Identifying patients with a poor outcome on currently recommended therapy might lead to further development of targeted therapies, eventually leading to improvements in outcome for patients with heart failure in Europe Campo scientifico natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicssocial sciencessociologydemographymortalitymedical and health sciencesclinical medicinecardiology Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH-2009-2.4.2-1 - Improved or new therapeutic approaches for the treatment of heart failure Invito a presentare proposte FP7-HEALTH-2009-single-stage Vedi altri progetti per questo bando Meccanismo di finanziamento CP-IP - Large-scale integrating project Coordinatore ACADEMISCH ZIEKENHUIS GRONINGEN Contributo UE € 3 345 849,15 Indirizzo HANZEPLEIN 1 9713 GZ Groningen Paesi Bassi Mostra sulla mappa Regione Noord-Nederland Groningen Overig Groningen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Carla Hooijschuur (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (10) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITA DEGLI STUDI DI BRESCIA Italia Contributo UE € 820 050,00 Indirizzo PIAZZA MERCATO 15 25121 Brescia Mostra sulla mappa Regione Nord-Ovest Lombardia Brescia Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Aldo Cuzzucoli (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FONDATION TRANSPLANTATION Francia Contributo UE € 489 855,00 Indirizzo rue de la Brot 4 21850 St Apollinaire Mostra sulla mappa Tipo di attività Research Organisations Contatto amministrativo Stéphanie Grojean (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Grecia Contributo UE € 489 999,60 Indirizzo 6 CHRISTOU LADA STR 10561 Athina Mostra sulla mappa Regione Αττική Aττική Κεντρικός Τομέας Αθηνών Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Efi Kafentzi (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF HULL Regno Unito Contributo UE € 490 017,45 Indirizzo COTTINGHAM ROAD HU6 7RX Hull Mostra sulla mappa Regione Yorkshire and the Humber East Yorkshire and Northern Lincolnshire Kingston upon Hull, City of Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Wayne Sheedy (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Paesi Bassi Contributo UE € 620 000,40 Indirizzo MEIBERGDREEF 15 1105AZ Amsterdam Mostra sulla mappa Regione West-Nederland Noord-Holland Groot-Amsterdam Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Clementia.C.M. (Tineke) Kranendonk-Van Der Ploeg (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIWERSYTET MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU Polonia Contributo UE € 489 999,60 Indirizzo UL PASTEURA 1 50 367 Wroclaw Mostra sulla mappa Regione Makroregion południowo-zachodni Dolnośląskie Miasto Wrocław Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Agnieszka Urbanska (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germania Contributo UE € 950 262,00 Indirizzo Chariteplatz 1 10117 Berlin Mostra sulla mappa Regione Berlin Berlin Berlin Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Eveline Fräßdorf (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato HELSE STAVANGER HF Norvegia Contributo UE € 389 280,00 Indirizzo GERD RAGNA BLOCH THORSENS GATE 8 4011 Stavanger Mostra sulla mappa Regione Norge Vestlandet Rogaland Tipo di attività Other Contatto amministrativo Kenneth Dickstein (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato UNIVERSITY OF LEICESTER Regno Unito Contributo UE € 2 939 250,00 Indirizzo UNIVERSITY ROAD LE1 7RH Leicester Mostra sulla mappa Regione East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicester Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Marie Adams (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF DUNDEE Regno Unito Contributo UE € 869 724,20 Indirizzo Nethergate DD1 4HN Dundee Mostra sulla mappa Regione Scotland Eastern Scotland Angus and Dundee City Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Chim Lang (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato