Obiettivo
The major outstanding challenges of orbivirus vaccine research is to develop vaccines that can afford a broad protective immune response against as many serotypes of each virus as possible, and to develop a high throughput DIVA assay (e.g. an ELISA). This project will use a coordinated multipartner approach to address these issues, to develop new experimental prototype vaccines and diagnostic approaches. It will build on specific expertise and reagents that are only available within the consortium and will link out to other international efforts in USA and South Africa to develop improved vaccines for these diseases. The consortium includes a number of industrial partners who are already active in vaccine manufacture for these and other veterinary diseases, in order to ensure that the findings of the research are transferred as soon as possible into commercial vaccines for European livestock. The project also includes two SMEs, who will be specifically involved in the development of DIVA compatible diagnostic tests. In summary, the specific objectives of the project will be: to develop multivalent vaccines using different approaches for Orbiviruses responsible for livestock diseases, in particular, Bluetongue Virus (BTV), African Horse Sickness Virus (AHSV) and Epizootic Haemorrhagic Disease Virus (EHDV); to understand the best vaccination strategy to elicit multi-serotype protection for these viruses in livestock and analyze immune responses for each of the novel vaccines developed for breadth of protection against multiple serotypes; and to develop DIVA compatible diagnostics that will work with the new vaccines developed in order to differentiate between vaccinated and infected animals.
Campo scientifico
Invito a presentare proposte
FP7-KBBE-2009-3
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Meccanismo di finanziamento
CP-FP - Small or medium-scale focused research projectCoordinatore
WC1E 7HT London
Regno Unito
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Partecipanti (17)
94700 Maisons Alfort
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28040 Madrid
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75016 Paris
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69007 Lyon
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17813 Vall De Bianya Girona
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Partecipazione conclusa
5831 AN Boxmeer
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55218 Ingelheim
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17493 Greifswald-Insel Riems
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6708 PB Wageningen
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0140 LYTTELTON CENTURION
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66506-1103 Manhattan Ks
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GU24 0NF Woking
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1180 BRUXELLES
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34790 Grabels
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28037 MADRID
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94701 MAISONS-ALFORT
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Partecipazione conclusa
17813 VALL DE BIANYA.-GIRONA
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