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Role of Epoxyeicosatrienoic Acids in the Regulation of Blood Pressure, Renal Hemodynamics and Sodium Excretion in Renovascular Model of Hypertension

Objective

Cytochrome P450 (CYP) metabolites are more frequently recognized as important regulators of cardiovascular and renal functions. CYP epoxygenases produce epoxyeicosatrienoic acids (EETs) that exhibit vasodilatory and natriuretic properties. EETs are degraded by the enzyme soluble epoxide hydrolase (sEH). Inhibition of sEH increases the level of EETs and attenuates blood pressure (BP) and end organ damage in several models of hypertension. We would like to define the role of EETs in BP regulation in the model of renovascular two kidney one clip (2K1C) hypertension. We will examine whether sEH inhibition attenuates BP and improves renal autoregulation and pressure natriuresis in 2K1C hypertension. In addition, we will study the signaling of EETs in isolated renal arterioles to determine the changes in EETs - mediated signal transduction in hypertension. Overall, these studies could elucidate the role of EETs in the regulation of renal functions and BP under physiological conditions and in hypertension. In addition, these studies could provide new evidence supporting the role of sEH inhibitor as the new candidate for antihypertensive therapy.

Call for proposal

FP7-PEOPLE-2009-RG
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Funding Scheme

MC-IRG - International Re-integration Grants (IRG)

Coordinator

Institut klinické a experimentální mediciny
Address
Videnska 1958/9
14021 Prague 4
Czechia
Activity type
Research Organisations
EU contribution
€ 75 000
Administrative Contact
Tomas Linhart (Mr.)