Objetivo Cytochrome P450 (CYP) metabolites are more frequently recognized as important regulators of cardiovascular and renal functions. CYP epoxygenases produce epoxyeicosatrienoic acids (EETs) that exhibit vasodilatory and natriuretic properties. EETs are degraded by the enzyme soluble epoxide hydrolase (sEH). Inhibition of sEH increases the level of EETs and attenuates blood pressure (BP) and end organ damage in several models of hypertension. We would like to define the role of EETs in BP regulation in the model of renovascular two kidney one clip (2K1C) hypertension. We will examine whether sEH inhibition attenuates BP and improves renal autoregulation and pressure natriuresis in 2K1C hypertension. In addition, we will study the signaling of EETs in isolated renal arterioles to determine the changes in EETs - mediated signal transduction in hypertension. Overall, these studies could elucidate the role of EETs in the regulation of renal functions and BP under physiological conditions and in hypertension. In addition, these studies could provide new evidence supporting the role of sEH inhibitor as the new candidate for antihypertensive therapy. Ámbito científico ciencias naturalesciencias químicasquímica inorgánicametales alcalinosciencias naturalesciencias biológicasbioquímicabiomoléculasproteínasenzima Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Convocatoria de propuestas FP7-PEOPLE-2009-RG Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IRG - International Re-integration Grants (IRG) Coordinador Institut klinické a experimentální mediciny Dirección Videnska 1958/9 14021 Prague 4 Chequia Ver en el mapa Región Česko Praha Hlavní město Praha Tipo de actividad Research Organisations Contacto administrativo Tomas Linhart (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Aportación de la UE Sin datos
