Skip to main content
Vai all'homepage della Commissione europea (si apre in una nuova finestra)
italiano it
CORDIS - Risultati della ricerca dell’UE
CORDIS
Contenuto archiviato il 2024-05-29

Mechanisms promoting the formation and migration of cruciform sister chromatid junctions during chromosome replication

Obiettivo

Eukaryotic cells replicate their genome by firing multiple replicons throughout the S phase of the cell cycle. Origin firing is a highly controlled process and is coupled with the formation of specialized cruciform junctions. These structures have been con served throughout evolution and likely contribute to the establishment of sister chromatid cohesion during S phase and to assist sister chromatid-mediated replication and recombination processes. Under pathological situations these sister chromatid junctions (SCJs) represent a source of DNA damage as they can be converted into reversed forks in the absence of a functional checkpoint or into recombination structures in cells defective in RecQ helicases. SCJs form at an early step of DNA synthesis and chase replication forks although the mechanims leading to their formation and migration remain elusive. M. Foiani and collaborators have extensively characterized the SCJs that form during replication in budding yeast both under physiological and pathological situation. The aim of the present proposal is to understand at the mechanistic level how these structures form during initiation of DNA synthesis and how they move through the replicon chasing replication forks.

Campo scientifico (EuroSciVoc)

Parole chiave

Argomento(i)

Invito a presentare proposte

FP6-2004-MOBILITY-5
Vedi altri progetti per questo bando

Meccanismo di finanziamento

EIF - Marie Curie actions-Intra-European Fellowships

Coordinatore

IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Contributo UE
Nessun dato
Costo totale
Nessun dato