Objetivo Terpenoids are a group of natural compounds that are extraordinary diverse in chemistry, structure and function. Most of the natural terpenoids are flexible and biocompatible biopolymers, having physico-chemical characteristics able to adapt to a wide variety of biologically active compounds. Surprisingly, they have never been used previously in the nanotechnology field for drug delivery and targeting purposes, except very recently by us to design squalene-based nanoassemblies. Thus, the current project aims to develop terpenoid-based nanoassemblies to improve the treatment of severe diseases incl. cancer, infectious and metabolic diseases. The conceptual approach is to chemically link a terpenoid to a biologically active drug molecule in order to allow the resulting bioconjugate to self-assemble as nanoparticles in water. Noteworthy, the nature of the polyterpenoid (ie. number of isoprenoid units) may be adapted to the hydrophilic/lipophilic character of the drug molecule to be transported, whereas the nature of the linkage (ester, amide, disulfide bonds etc.) will be selected according to the enzymatic content of the targeted diseased area. From the ratio between drug s and polyterpene s molecular weights, it is deduced that the drug loading will be dramatically improved as compared to the currently available nanomedicines. In other words, the pro-drug will form the nanomedicine by selfaggregation without the need of any other transporter material. The project will involve the following interdisciplinary aspects:(i) synthesis of drug/polyterpene bioconjugates,(ii)design of the nanoassemblies and their functionalization with recognition ligands,(iii)cell and tissue imaging and(iv)pharmacological evaluation in vitro (cell culture) and in vivo. Such ambitious and challenging project will be performed under Patrick Couvreur s leadership who has settled up a worldwide recognized multidisciplinary research team, unique in the nanomedicine world. Ámbito científico medical and health sciencesmedical biotechnologynanomedicinemedical and health sciencesclinical medicineoncologyengineering and technologynanotechnologynano-materials Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health Convocatoria de propuestas ERC-2009-AdG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-AG - ERC Advanced Grant Institución de acogida UNIVERSITE PARIS-SUD Aportación de la UE € 1 916 799,00 Dirección RUE GEORGES CLEMENCEAU 15 91405 ORSAY CEDEX Francia Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Investigador principal Patrick Couvreur (Prof.) Contacto administrativo Nicolas Lecompte (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITE PARIS-SUD Francia Aportación de la UE € 1 916 799,00 Dirección RUE GEORGES CLEMENCEAU 15 91405 ORSAY CEDEX Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Investigador principal Patrick Couvreur (Prof.) Contacto administrativo Nicolas Lecompte (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Francia Aportación de la UE € 120 000,00 Dirección RUE LEBLANC 25 75015 PARIS 15 Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Research Organisations Contacto administrativo Eliane Deck-Chaumont (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos BERTIN PHARMA Francia Aportación de la UE € 150 000,00 Dirección Avenue Ampère 10Bis 78180 Montigny le Bretonneux Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Alain Champoudry (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITE CATHOLIQUE DE LOUVAIN Bélgica Aportación de la UE € 12 000,00 Dirección PLACE DE L UNIVERSITE 1 1348 Louvain La Neuve Ver en el mapa Región Région wallonne Prov. Brabant Wallon Arr. Nivelles Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Anne Bovy (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos