Obiettivo Terpenoids are a group of natural compounds that are extraordinary diverse in chemistry, structure and function. Most of the natural terpenoids are flexible and biocompatible biopolymers, having physico-chemical characteristics able to adapt to a wide variety of biologically active compounds. Surprisingly, they have never been used previously in the nanotechnology field for drug delivery and targeting purposes, except very recently by us to design squalene-based nanoassemblies. Thus, the current project aims to develop terpenoid-based nanoassemblies to improve the treatment of severe diseases incl. cancer, infectious and metabolic diseases. The conceptual approach is to chemically link a terpenoid to a biologically active drug molecule in order to allow the resulting bioconjugate to self-assemble as nanoparticles in water. Noteworthy, the nature of the polyterpenoid (ie. number of isoprenoid units) may be adapted to the hydrophilic/lipophilic character of the drug molecule to be transported, whereas the nature of the linkage (ester, amide, disulfide bonds etc.) will be selected according to the enzymatic content of the targeted diseased area. From the ratio between drug s and polyterpene s molecular weights, it is deduced that the drug loading will be dramatically improved as compared to the currently available nanomedicines. In other words, the pro-drug will form the nanomedicine by selfaggregation without the need of any other transporter material. The project will involve the following interdisciplinary aspects:(i) synthesis of drug/polyterpene bioconjugates,(ii)design of the nanoassemblies and their functionalization with recognition ligands,(iii)cell and tissue imaging and(iv)pharmacological evaluation in vitro (cell culture) and in vivo. Such ambitious and challenging project will be performed under Patrick Couvreur s leadership who has settled up a worldwide recognized multidisciplinary research team, unique in the nanomedicine world. Campo scientifico medical and health sciencesmedical biotechnologynanomedicinemedical and health sciencesclinical medicineoncologyengineering and technologynanotechnologynano-materials Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health Invito a presentare proposte ERC-2009-AdG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-AG - ERC Advanced Grant Istituzione ospitante UNIVERSITE PARIS-SUD Contributo UE € 1 916 799,00 Indirizzo RUE GEORGES CLEMENCEAU 15 91405 ORSAY CEDEX Francia Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Patrick Couvreur (Prof.) Contatto amministrativo Nicolas Lecompte (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (4) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITE PARIS-SUD Francia Contributo UE € 1 916 799,00 Indirizzo RUE GEORGES CLEMENCEAU 15 91405 ORSAY CEDEX Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Patrick Couvreur (Prof.) Contatto amministrativo Nicolas Lecompte (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Francia Contributo UE € 120 000,00 Indirizzo RUE LEBLANC 25 75015 PARIS 15 Mostra sulla mappa Regione Ile-de-France Ile-de-France Paris Tipo di attività Research Organisations Contatto amministrativo Eliane Deck-Chaumont (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato BERTIN PHARMA Francia Contributo UE € 150 000,00 Indirizzo Avenue Ampère 10Bis 78180 Montigny le Bretonneux Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Alain Champoudry (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITE CATHOLIQUE DE LOUVAIN Belgio Contributo UE € 12 000,00 Indirizzo PLACE DE L UNIVERSITE 1 1348 Louvain La Neuve Mostra sulla mappa Regione Région wallonne Prov. Brabant Wallon Arr. Nivelles Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Anne Bovy (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato