Objectif Terpenoids are a group of natural compounds that are extraordinary diverse in chemistry, structure and function. Most of the natural terpenoids are flexible and biocompatible biopolymers, having physico-chemical characteristics able to adapt to a wide variety of biologically active compounds. Surprisingly, they have never been used previously in the nanotechnology field for drug delivery and targeting purposes, except very recently by us to design squalene-based nanoassemblies. Thus, the current project aims to develop terpenoid-based nanoassemblies to improve the treatment of severe diseases incl. cancer, infectious and metabolic diseases. The conceptual approach is to chemically link a terpenoid to a biologically active drug molecule in order to allow the resulting bioconjugate to self-assemble as nanoparticles in water. Noteworthy, the nature of the polyterpenoid (ie. number of isoprenoid units) may be adapted to the hydrophilic/lipophilic character of the drug molecule to be transported, whereas the nature of the linkage (ester, amide, disulfide bonds etc.) will be selected according to the enzymatic content of the targeted diseased area. From the ratio between drug s and polyterpene s molecular weights, it is deduced that the drug loading will be dramatically improved as compared to the currently available nanomedicines. In other words, the pro-drug will form the nanomedicine by selfaggregation without the need of any other transporter material. The project will involve the following interdisciplinary aspects:(i) synthesis of drug/polyterpene bioconjugates,(ii)design of the nanoassemblies and their functionalization with recognition ligands,(iii)cell and tissue imaging and(iv)pharmacological evaluation in vitro (cell culture) and in vivo. Such ambitious and challenging project will be performed under Patrick Couvreur s leadership who has settled up a worldwide recognized multidisciplinary research team, unique in the nanomedicine world. Champ scientifique medical and health sciencesmedical biotechnologynanomedicinemedical and health sciencesclinical medicineoncologyengineering and technologynanotechnologynano-materials Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health Appel à propositions ERC-2009-AdG Voir d’autres projets de cet appel Régime de financement ERC-AG - ERC Advanced Grant Institution d’accueil UNIVERSITE PARIS-SUD Contribution de l’UE € 1 916 799,00 Adresse RUE GEORGES CLEMENCEAU 15 91405 ORSAY CEDEX France Voir sur la carte Type d’activité Higher or Secondary Education Establishments Chercheur principal Patrick Couvreur (Prof.) Contact administratif Nicolas Lecompte (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITE PARIS-SUD France Contribution de l’UE € 1 916 799,00 Adresse RUE GEORGES CLEMENCEAU 15 91405 ORSAY CEDEX Voir sur la carte Type d’activité Higher or Secondary Education Establishments Chercheur principal Patrick Couvreur (Prof.) Contact administratif Nicolas Lecompte (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France Contribution de l’UE € 120 000,00 Adresse RUE LEBLANC 25 75015 PARIS 15 Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Eliane Deck-Chaumont (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée BERTIN PHARMA France Contribution de l’UE € 150 000,00 Adresse Avenue Ampère 10Bis 78180 Montigny le Bretonneux Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Alain Champoudry (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITE CATHOLIQUE DE LOUVAIN Belgique Contribution de l’UE € 12 000,00 Adresse PLACE DE L UNIVERSITE 1 1348 Louvain La Neuve Voir sur la carte Région Région wallonne Prov. Brabant Wallon Arr. Nivelles Type d’activité Higher or Secondary Education Establishments Contact administratif Anne Bovy (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
