Changing the rules for aromatic substitution reactions: Development of a general meta-selective copper-catalyzed C–H bond functionalization strategy

Projektinformationen

META-ARYL

ID Finanzhilfevereinbarung: 253650

Projekt abgeschlossen

Startdatum 1 Mai 2010

Enddatum 30 April 2012

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 172 740,80

EU-Beitrag € 172 740,80

Koordiniert durch

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Ziel

This proposal details a new Cu(II) catalysed reactivity concept that will enable the selective C–H bond functionalisation of an important class of aromatic compounds. In particular, a meta-selective C–H arylation of arylacetamides will be the focus of this study. Furthermore, this strategy could also be used to assemble the potent antibiotic, arylomycin A2 as well as facilitate the convenient synthesis of analogues that could be used to probe bacterial resistance, leading to new antibiotic treatments. Our preliminary studies have suggested that this type of transformation is viable for the C–H functionalisation of indoles, acetanilides and anisoles. The capacity to selectively functionalise the C–H bonds of a simple, or complex molecule will be a powerful tool for chemical synthesis and could impact on treatment of diseases.

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antibiotics
• natural sciences › chemical sciences › organic chemistry › aromatic compounds

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2009-IEF - Marie Curie Action: "Intra-European Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2009-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Kontakt Verwaltung

Keith Cann (Mr.)

• EU-Beitrag: € 172 740,80
• Adresse: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge ; Vereinigtes Königreich
• Region: East of England › East Anglia › Cambridgeshire CC
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten