Cel This proposal details a new Cu(II) catalysed reactivity concept that will enable the selective C–H bond functionalisation of an important class of aromatic compounds. In particular, a meta-selective C–H arylation of arylacetamides will be the focus of this study. Furthermore, this strategy could also be used to assemble the potent antibiotic, arylomycin A2 as well as facilitate the convenient synthesis of analogues that could be used to probe bacterial resistance, leading to new antibiotic treatments. Our preliminary studies have suggested that this type of transformation is viable for the C–H functionalisation of indoles, acetanilides and anisoles. The capacity to selectively functionalise the C–H bonds of a simple, or complex molecule will be a powerful tool for chemical synthesis and could impact on treatment of diseases. Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsnatural scienceschemical sciencesorganic chemistryaromatic compounds Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2009-IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Zaproszenie do składania wniosków FP7-PEOPLE-2009-IEF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IEF - Intra-European Fellowships (IEF) Koordynator THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Wkład UE € 172 740,80 Adres TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Zjednoczone Królestwo Zobacz na mapie Region East of England East Anglia Cambridgeshire CC Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Keith Cann (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
