Final Report Summary - APL (ANALYSIS OF PML/RARA ONCOGENIC COMPLEX IN ACUTE PROMYELOCYTIC LEUKEMIA)
Pharmacologic concentrations of RA trigger the dissociation of the correpressor complex and the recruitment of the coactivator complex, and lead to changes in gene expression, APL cell differentiation, but also degrade the fusion via proteasome by the retinoic acid‐bound RARα moiety of PML-RARα. It has been suggested that while transcriptional activation control differentiation, this may not be the primary basis for the therapeutic efficacy of RA in clearing APL-associated t(15;17). Indeed, only the leukemia initiating cells (LICs) clearance is responsible for the remission of mouse APL and high concentrations of RA are required for complete PML-RARα catabolism and full LIC clearance.