Objective
One of the most worrying issues in public health is the recent and dramatic increase of hospital and community acquired infections mediated by uropathogenic (UPEC) multidrug resistant Escherichia coli clones. Recent epidemiological studies highlighted the implication of specific E. coli lineages from different genetic backgrounds in the spread of particular antibiotic resistance genes in wide geographic areas and settings. However, the reasons motivating their fast emergence and amplification and/or the factors influencing pathogenicity, adhesion and persistence are poorly understood, hindering the design of measures to curtail their spread. To gain insights into the role of these clonal groups, it would be necessary to extend the knowledge on their global distribution, identify transmission pathways and deepen in the characterization of their virulence and pathogenic profile. High-throughput methods could be valuable to complement genotypic methods in the identification of targets for clinically relevant clones’ detection, and to optimize global surveillance approaches. Although an appropriate validation and selection of statistical analysis methods is needed to consolidate their application in medical microbiology, fourier transform infrared spectroscopy (FTIR) has proved to be discriminatory at different bacterial taxonomic levels and might be a promising tool to assist large-scale epidemiological studies. We propose to apply a multidisciplinary and dynamic approach encompassing FTIR and conventional genotypic methods for identification and characterization of representative UPEC-multidrug resistant E. coli clones, recently responsible for the spread of extended-spectrum β-lactamases. This proposal includes fundamental research EU high priority areas with potential translation to human health, and the application of innovative and multidisciplinary strategies promoting research’s cooperativeness, inter-sectoral transfer of knowledge and global competitiveness.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
- natural sciences biological sciences microbiology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4051 401 Porto
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.