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Analysis of regulatory T cell proliferation and apoptosis in vivo at the cellular and molecular level

Objectif

Foxp3+ regulatory T cells are critical for controlling the degree of immune activation during infection, autoimmunity and allergy. Despite the importance of this cell lineage to human health, relatively little is known about the molecular and cellular control of their differentiation and homeostasis. In order to rectify this deficit we propose to investigate the properties of proliferation and apoptosis during expansion, contraction and homeostatic stages, using sophisticated genetic models. We will also investigate the role of Bcl-2 family member genes and the IL2 / Pdl1 axis in the molecular control over these cellular properties. By dissecting the factors controlling regulatory T cell numbers we ultimately seek routes to make this process amenable to therapeutic manipulation.

Champ scientifique (EuroSciVoc)

Programme(s)

Thème(s)

Appel à propositions

FP7-PEOPLE-2009-RG
Voir d’autres projets de cet appel

Régime de financement

MC-IRG - International Re-integration Grants (IRG)

Coordinateur

VIB VZW
Contribution de l’UE
€ 100 000,00
Adresse
SUZANNE TASSIERSTRAAT 1
9052 ZWIJNAARDE - GENT
Belgique
Région
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Type d’activité
Research Organisations
Liens
Coût total
Aucune donnée