Skip to main content
Vai all'homepage della Commissione europea (si apre in una nuova finestra)
italiano it
CORDIS - Risultati della ricerca dell’UE
CORDIS
Contenuto archiviato il 2024-06-18

Analysis of regulatory T cell proliferation and apoptosis in vivo at the cellular and molecular level

Obiettivo

Foxp3+ regulatory T cells are critical for controlling the degree of immune activation during infection, autoimmunity and allergy. Despite the importance of this cell lineage to human health, relatively little is known about the molecular and cellular control of their differentiation and homeostasis. In order to rectify this deficit we propose to investigate the properties of proliferation and apoptosis during expansion, contraction and homeostatic stages, using sophisticated genetic models. We will also investigate the role of Bcl-2 family member genes and the IL2 / Pdl1 axis in the molecular control over these cellular properties. By dissecting the factors controlling regulatory T cell numbers we ultimately seek routes to make this process amenable to therapeutic manipulation.

Campo scientifico (EuroSciVoc)

Argomento(i)

Invito a presentare proposte

FP7-PEOPLE-2009-RG
Vedi altri progetti per questo bando

Meccanismo di finanziamento

MC-IRG - International Re-integration Grants (IRG)

Coordinatore

VIB VZW
Contributo UE
€ 100 000,00
Indirizzo
SUZANNE TASSIERSTRAAT 1
9052 ZWIJNAARDE - GENT
Belgio
Regione
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Tipo di attività
Research Organisations
Collegamenti
Costo totale
Nessun dato