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Magnetic Isolation and moleculaR Analysis of single CircuLating and disseminated tumor cElls on chip

Descrizione del progetto

Microsystems and Smart Miniaturised Systems

Cancer remains a prominent health concern afflicting modern societies. Continuous innovations and introduction of new technologies are essential to level or even reduce current healthcare spending. As the analysis of occult tumour cells (OTC) in blood or bone marrow is most promising in this respect, MIRACLE aims to develop a low-cost, fully automated, integrated lab-on-a-chip (LOC) system for the isolation, counting and characterization of OTCs starting from clinical samples.A major challenge for OTC detection is their extremely low concentration (below a single cell per mL) in clinical samples. Current detection methods are often based on enrichment techniques followed by cumbersome microscopic analysis of the cell phenotype. Some of these procedure steps have been semi-automated (Cellsearch®, J&J), but the interpretation of the cell morphology requires expertise and remains partially subjective. In contrary to standard phenotyping tests, MIRACLE aims to determine the genotype by integrating all sample processing and detection steps in a miniaturized system. This envisaged, fully-automated MIRACLE test would yield decisive results within half a day for less than 50 EUR, as compared with contemporary diagnostics tests that may take days.With the essential individual modules recently demonstrated on automated chips in a joint project by some of the partners involved (MASCOT FP6 027652), the MIRACLE's consortium is uniquely positioned to lead the project's main objectives to a successful outcome, well ahead of the current state-of-the-art. Combining the team's multidisciplinary and unique expertise avoids unnecessary overlap. Integrating all components into a fully operational LOC platform will represent an immense advance for Europe to cope with interfacing and integration problems generic to microfluidic and smart miniaturized systems. More importantly, the realisation of the MIRACLE vision will revolutionise cancer diagnostics and individualized theranostics.

Campo scientifico

Programma(i)

Argomento(i)

Invito a presentare proposte

FP7-ICT-2009-5
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Meccanismo di finanziamento

CP - Collaborative project (generic)

Coordinatore

INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
Contributo UE
€ 1 669 975,00
Indirizzo
KAPELDREEF 75
3001 Leuven
Belgio

Mostra sulla mappa
Regione
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Tipo di attività
Research Organisations
Contatto amministrativo
Christine Van Houtven (Mrs.)
Collegamenti
Costo totale
Nessun dato

Partecipanti (14)

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Ultimo aggiornamento: 16 Luglio 2019

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Permalink: https://cordis.europa.eu/project/id/257743/it

European Union, 2024