Objective
Supramolecular chemistry and nanofabrication methods provide excellent prospect to construct reversible dynamic biological nanoplatforms employed for supramolecular cell manipulation (SUMOMAN) experiments. Making use of supramolecular chemistry is a rewarding task in developing functional materials and devices. Knowing the limitations involved in ordering proteins at different length scales will surely hasten the development of future applications, supramolecular nanobiology being the most prominent. The construction of synthetic supramolecular assemblies of proteins provides an excellent tool to fabricate organized bioactive components in the sub-micron regime at surfaces. Supramolecular nanobiology narrows the gap between chemical biology and bionanotechnology. The latter devises ways to construct molecular devices using biomacromolecules and it attempts to build molecular machines utilizing concepts seen in nature. In chemical biology new synthesis methods and strategies are developed and employed for the synthesis of compounds which are used as probes for the study of biological phenomena. Steadily improved synthetic procedures for site-specific modification of proteins have gained more control over structure and function of the proteins. However, applications of protein chips remain hampered by orientational and conformational aspects at the surface.
With the development of supramolecular bioactive nano-platforms on surfaces serving as a reversible dynamic interface to cells, the goal to study and manipulate cellular processes will come closer.
An innovative construction process of biological nanoarrays is proposed to study important fundamental aspects of cell biology. When such structured surfaces display a biological interface with nm resolution, a lengthscale inherently more relevant to biorecognition than microlengthscales, the communication through biomolecules with cellular receptors can be modulated with unprecedented spatial and temporal specificity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2010-StG_20091028
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
7522 NB Enschede
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.