Obiettivo
Among patients with adrenal masses Adrenocortical carcinoma (ACC) and malignant pheochromocytomas (MPH) are found with a low incidence but very unfavorable prognosis. Due to this poor clinical outcome, concomitant hormone dysregulation and limited treatment options the two cancer entities severely impact on affected patients. However, the rarity of the tumors also impedes clinical studies which are affected by fragmentation and low cohort sizes.
The European Network for the Study of Adrenal Tumors (ENS@T) has recently implemented a collection of adrenal tumor related databases and defined an associated network of Biological Resource Centers devoted to research on adrenal tumors. The concurrence of recent achievements of this evolving network, the progress in the understanding of molecular mechanisms and increasing availability of specific diagnostic and therapeutic tools for adrenal cancers provides the unique opportunity to achieve unmatched progress in the implementation of both translation and clinical research dedicated to ACC and MPH. Specifically, the newly formed ENS@T-CANCER consortium will address the following topics: 1. Structuring European clinical and translational research through implementation of a virtual research environment, 2. Improving clinical outcome of patients with adrenal cancer by conducting interventional trials carried out by European centers of excellence, 3. Improvement of differential diagnosis and risk stratification of adrenal cancer, 4. Identification and validation of tools for follow-up of patients with adrenal cancer, 5. Identification of novel biomarkers for treatment response.
The ultimate aim of the ENS@T-CANCER Consortium is to develop research in the field of adrenal cancers to improve diagnosis and treatment abilities. The Network will allow recruiting sufficient patients in all relevant European centers, to harmonize diagnosis criteria and to use the various technological approaches of a number of laboratories.
Campo scientifico
Argomento(i)
Invito a presentare proposte
FP7-HEALTH-2010-two-stage
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Meccanismo di finanziamento
CP-FP - Small or medium-scale focused research projectCoordinatore
80539 MUNCHEN
Germania
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Partecipanti (16)
75794 Paris
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75654 Paris
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3015 GD Rotterdam
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50121 Florence
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28029 Madrid
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B15 2TT Birmingham
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01069 Dresden
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97080 Wurzburg
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6525 XZ Nijmegen
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10124 Torino
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94805 Villejuif
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35122 Padova
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Partecipazione conclusa
80333 Muenchen
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3010 Melbourne
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35037 Marburg
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75008 Paris
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