Final Report Summary - RNANTIBIOTICS (RNA-mediated virulence gene regulation: Identification of novel antibacterial compounds)
For the second part of the Project, bacterial stress-regulation, we unexpectedly identified cycles of light and dark to coordinate bacterial development through a blue-light receptor. We found that the sensing of light triggered a very complex response involving the stress-sigma factor, sigmaB and a protein complex known as the "stressosome".