Final Report Summary - NANOBIOPHARMACEUTICS (Nanoscale functionalities for targeted drug delivery of biopharmaceutics)
The undertaken activities were organised in various distinct, yet interrelated, Work packages (WPs) which analysed the following project components:
1. polymer P/P nanoaggregates and systems for targeted P/P delivery;
2. toxicity, immunogenicity and degradation testing;
3. interaction between cells and nanostructures;
4. nasal delivery;
5. oral P/P delivery systems;
6. P/P delivery systems for crossing the blood brain barrier (BBB).
The predefined objectives and milestones of NANOBIOPHARMACEUTICS were successfully met in full accordance with the work plan, the consortium agreement and all ethical guidelines. The project was very successful in terms of producing, testing and implementing numerous nanoparticulate carrier systems, the so-called 'NanoToolbox'. These systems, combined with peptides, were the basis for in vitro and in vivo tests addressing the oral, nasal and BBB administrative routes.
For the oral administrative route, a real breakthrough was achieved and a patent was filed. For the nasal and BBB routes very promising systems were developed, which were anticipated to form the basis for further developments in order to establish systems which might also be used in clinical testing. In addition to these application oriented developments, a deep understanding of possible interactions of the nanocarriers with cell systems was generated.
The acquired knowledge was successfully disseminated through several paths. Firstly, a project website was created and continuously updated. Moreover, several scientific publications were produced and two conferences were organised as part of the project. In addition, team members were invited to present the project progress in various events, while training activities on different topics were provided by the consortium.