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Fabrication of particles with photo receptors: bio-analytical application such as controlled drug delivery

Objectif

The importance of carbon-based materials in biological applications has been recognized. Especially, nanodiamond particles (referred to as nanodiamonds, NDs) have started to emerge as novel candidate for promising applications in the field of nano-biotechnology as imaging probes and drug carriers. NDs do not show the toxicity of other nanoparticles, notably gold, making them ideal nanoscale drug delivery platforms. Furthermore, NDs can exhibit intrinsic fluorescence from point defects making them candidates for biomedical imaging applications. ND particles are particularly attractive for biomedical applications as functionalization and biomolecule immobilization are readily accomplished. Triggered drug release allows the functionalized NDs to find their targets before the drugs are activated by local conditions. In this sense, the NDs are performing the well established role of postdrugs, smuggeling the inactive compound to their targets where they are released through bond cleavage.
The objective of the proposed program concerns the fabrication of NDs modified with photo-label linkers where different molecules can be directly attached, without chemically modification of the biomolecule itself. In a proof of principle, horse radish peroxidase (HRP) will be linked to NDs modified with the photo-label o-nitrobenzyl group and the release followed by UV/Vis. In a later state the controlled release of drugs such as ibuprofen, adriamycin or antigens will be looked at.
The proposed research project brings together centers from France, the UK, Spain and the Ukrain. The network offers training in the fabrication and characterization of new materials for biological applications.

Appel à propositions

FP7-PEOPLE-2010-IRSES
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Coordinateur

UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE - LILLE I
Adresse
Cite Scientifique Batiment A3
59655 Villeneuve D'ascq
France
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 66 500
Contact administratif
Sabine Szunerits (Prof.)

Participants (4)

UNIVERSITY OF BRIGHTON
United Kingdom
Contribution de l’UE
€ 47 500
Adresse
Lewes Road Mithras House
BN2 4AT Brighton
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Peter Cragg (Dr.)
UNIVERSITE DE PICARDIE JULES VERNE
France
Contribution de l’UE
€ 36 100
Adresse
Chemin Du Thil
80025 Amiens
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Veaceslav Grosu (Mr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Espagne
Contribution de l’UE
€ 20 900
Adresse
Calle Serrano 117
28006 Madrid
Type d’activité
Research Organisations
Contact administratif
Eusebio Jiménez Arroyo (Mr.)
UNIVERSIDAD DE SEVILLA
Espagne
Contribution de l’UE
€ 15 200
Adresse
Calle S. Fernando 4
41004 Sevilla
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Margarita Martinez-Pais Loscertales (Ms.)