Objectif Harmful Algal blooms (HABs) are a global issue with economic, ecologic and biomedical implications. Shellfish mortalities associated with HABs have been observed. Algal toxins accumulate in some bivalves whereas other species won't display similar accumulation. Furthermore, one species may respond differentially to various toxins, which causes difficulties to generalize the mechanisms involved. Only very few studies investigated cellular and molecular mechanisms occurring during HAB exposure. Exposure of bivalves to HABs may induce an inflammatory response involving hemocytes and oxidative activity. The need to understand cellular and molecular mechanisms during the response of bivalves to HABs appears necessary. At the cellular level, hemocytes may play primordial role. At the molecular level, oxidative stresses might be of extreme importance. The objectives of this project are to characterise the cellular and molecular inflammatory responses and oxidative activities of oysters to HAB exposure, and the potential involvement of hemocytes in transportation of toxin. In vivo exposures and oysters collected in situ during algal blooms will allow the evaluation of inflammatory response, oxidative and anti-oxidant activities, and localisation of algal toxins in the tissues. In vitro experiments will help to assess the interactions between hemocytes and algal cells, and cellular and molecular mechanisms directing the response, as well as the capacity of hemocytes to acquire and depurate the algal toxins. Gathering in vitro and in vivo / in situ results will provide understanding of the cellular and molecular events taking place during bivalve exposure to HABs. Such knowledge will help determine which are the key phenomena leading to toxin accumulation or detoxification. This research will allow to further investigate how the physiological state of bivalves can influence toxin accumulation, and will provide information for shellfish aquaculture, restoration and management. Champ scientifique agricultural sciencesagriculture, forestry, and fisheriesfisheriessocial sciencessociologydemographymortality Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2010-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Appel à propositions FP7-PEOPLE-2010-IOF Voir d’autres projets de cet appel Régime de financement MC-IOF - International Outgoing Fellowships (IOF) Coordinateur CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Contribution de l’UE € 239 034,40 Adresse RUE MICHEL ANGE 3 75794 Paris France Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Anne Fagon (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
