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Contenido archivado el 2024-05-30

Physiological function and potential therapeutic utility of the neuropeptide galanin in airway inflammation

Objetivo

The results of studies of the physiological and pathophysiological effects of peptides have guided the development of two principal classes of therapeutic agents: small molecules able to block the action of peptide receptors and synthetic peptides mimicking the actions of endogenous molecules. Within this arena, the effects of neuropeptides on the central nervous system (CNS) have been studied intensively for more than 20 years, leading to several therapeutic products that are in clinical development. However, it is now clear, that the actions of neuropeptides are far more diverse than previously thought. Another area with great pharmacologic potential encompasses the peripheral actions of the neuropeptide galanin. Lately, galanin has been shown to exhibit potent anti-inflammatory action in the skin and recent data indicate that galanin is also involved in the physiology and the immune system of the airways. Consequently, we hypothesise that galanin is a crucial regulator of airway inflammation and vascular tone in the lung. We further propose that galanin exerts its effects at different cellular levels within the pulmonary system. The aim of this study is to determine novel/specific functions and sites of action of galanin in the respiratory system and to evaluate the therapeutic potential of galanin on airway inflammation and hyperreactivity. To achieve these specific aims we will take a multidisciplinary approach, employing molecular and cell biology, pharmacology, in vivo animal model and clinical research. The outcomes of this study will precisely define the role of galanin in the respiratory system and may suggest novel therapeutic strategies for the control of asthma, chronic bronchitis or other inflammatory pulmonary disorders. The findings from this research may also be relevant to the process of chronic inflammation in other organs, such as skin, joints and the gastrointestinal tract.

Ámbito científico (EuroSciVoc)

Programa(s)

Tema(s)

Convocatoria de propuestas

FP7-PEOPLE-2010-IIF
Consulte otros proyectos de esta convocatoria

Régimen de financiación

MC-IIF - International Incoming Fellowships (IIF)

Coordinador

GEMEINNUTZIGE SALZBURGER LANDESKLINIKEN BETRIEBSGESELLSCHAFT
Aportación de la UE
€ 175 844,80
Coste total
Sin datos