Objective
"One of the traditional approaches for the treatment of prostate cancer is the administration of steroid-derived Androgen Receptor (AR) antagonists. These treatments show significant side effects due to their high dosing requirements. In a novel intervention approach Molecular Design Group (Trinity College Dublin), has used a variety of computational drug discovery techniques to analyse a recently identified, non-steroid AR protein binding site, termed the activation function 2 (AF2) site. The goal of this proposal is to perform lead optimisation for the development of new drugs that combat prostate cancer in a different way, circumventing the observed resistance.
The project will be implemented at Trinity College Dublin (TCD), Ireland's leading research University, supervised by Dr David Lloyd and Dr Darren Fayne, from Molecular Design Group (TCD), on the computational methodologies, Prof Mary Meegan, from the School of Pharmacy and Pharmaceuticals Studies (TCD), on the synthetic methodologies and Prof Clive Williams, from the School of Biochemistry and Immunology (TCD) on the biological assays. The responsibilities of the experienced researcher, Dr. Fernando Blanco, within the project will focus on the rational computational design and synthesis of new potential pharmaceuticals, receiving multidisciplinary training combining computational strategies, synthesis and biological assays, as well as other fundamental aspects (managing and administering of a research programme) related to strengthen the abilities of the Dr. Blanco to become a leading independent researcher in the field.
The completion of the present project is a major step in the research career of Dr. Blanco to successfully reach a position of professional maturity. In addition, the development of new small molecules to treat prostate cancer and have an impact upon translational research that will lead to clinical applications for cancer treatments is a central priority in Europe."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences clinical medicine oncology prostate cancer
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences basic medicine immunology
- natural sciences computer and information sciences artificial intelligence computational intelligence
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
D02 CX56 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.