Final Report Summary - IPSMILD (HUMAN INDUCED PLURIPOTENT STEM CELLS AS A MODEL TO STUDY METABOLIC INHERITED LIVER DISEASES)
In parallel, to study the effect of the loss of PCSK9 on HLC differentiation and function, we generated and characterized three hiPSC lines expressing shRNA directed against PCSK9 and analyzed their effects.
The conduction of this project and the development of cellular tools to achieve it allowed me to strongly integrate the host laboratory (L’institut du thorax, UMR INSERM1087/CNRS6291, IRS-UN Nantes) and setup several collaborations with local, national and international research teams. This environment is particularly favorable for the development and the emergence of my research team as well as its visibility at the international level. I am currently applying for a tenure track position in order to sustain my research activities in the field within my current host laboratory.