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Development of novel treatment strategies based on knowledge of cellular dysfunction in diabetes

Objetivo

A reduction in functional pancreatic beta cell mass is the key feature of type 1 and type 2 diabetes. Beta cell failure is exacerbated in the context of obesity and insulin resistance. Brown adipose tissue (BAT) is a highly metabolic organ, mediating energy dissipation and glucose disposal, thus contributing to maintain energy balance. BAT dysfunction contributes to obesity and impaired glucose metabolism, increasing functional demand on the beta cells. The cellular dysfunction of beta cells and BAT in diabetes is the fruit of defective signal transduction and organelle function, and the vulnerability to these molecular defects may be modulated by diabetes genes. To identify the crosstalk and pathways responsible for beta cell and BAT dysfunction and beta cell apoptosis in diabetes at its real level of complexity, this consortium will use cutting edge genetics, functional (epi)genomics, molecular biology and computational tools to reach an accurate organelle and cell diagnosis. This diagnosis will be used to define novel targets for intervention to prevent dysfunction and facilitate recovery of functionally impaired metabolic tissues. Some of these targets have already been identified by consortium members, including endoplasmic reticulum (ER) stress and mitochondrial dysfunction and apoptosis. Since many of these targets are related to dysfunction of specific organelles, we will focus on the novel concept of organelle therapy, aiming to preserve mitochondrial and ER function by the use of viral vectors and small molecule chemical probes. We will thus follow a two-pronged approach, namely a focused approach to restore known and specific cellular/organelle dysfunctions and a systems biology approach to identify novel targets for intervention. This, in combination with high throughput screening of large compound libraries, will translate discoveries into innovative therapeutic strategies that halt destruction and facilitate recovery of cell dysfunction in diabetes.

Convocatoria de propuestas

FP7-HEALTH-2011-two-stage
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Coordinador

UNIVERSITE LIBRE DE BRUXELLES
Dirección
Avenue Franklin Roosevelt 50
1050 Bruxelles
Bélgica
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 1 354 000
Contacto administrativo
Angelique Greindl (Ms.)

Participantes (10)

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Aportación de la UE
€ 994 000
Dirección
Trinity Lane The Old Schools
CB2 1TN Cambridge
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Renata Schaeffer (Ms.)
UNIVERSITE DE LAUSANNE
Suiza
Aportación de la UE
€ 497 000
Dirección
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Nicole Vouilloz (Ms.)
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Estados Unidos
Aportación de la UE
€ 450 000
Dirección
North Torrey Pines Road 10901
92037 1005 La Jolla Ca
Tipo de actividad
Research Organisations
Contacto administrativo
Kathlyn L. Huson (Ms.)
UNIVERSITAT DE BARCELONA
España
Aportación de la UE
€ 474 000
Dirección
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Xavier Gutiérrez (Mr.)
MAX IV Laboratory, Lund University
Suecia
Aportación de la UE
€ 485 000
Dirección
Paradisgatan 5C
22100 Lund
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Jacqueline Postma (Dr.)
TEKNOLOGIAN TUTKIMUSKESKUS VTT

La participación finalizó

Finlandia
Aportación de la UE
€ 286 333,60
Dirección
Tekniikantie 4 A
02044 VTT Espoo
Tipo de actividad
Research Organisations
Contacto administrativo
Sinikka Soirinsuo (Ms.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Alemania
Aportación de la UE
€ 482 000
Dirección
Carl-neuberg-strasse 1
30625 Hannover
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Angela Steinhusen (Ms.)
DNA VISION SA
Bélgica
Aportación de la UE
€ 356 000
Dirección
Avenue G Lemaitre 25
6041 Gosselies
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Dimitri Lhoste (Mr.)
SIRION BIOTECH GMBH
Alemania
Aportación de la UE
€ 411 000
Dirección
Am Klopferspitz 19
82152 Planegg Martinsried
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Christian Thirion (Dr.)
NOVO NORDISK INVEST 4 A/S
Dinamarca
Aportación de la UE
€ 209 666,40
Dirección
Novo Alle 1
2880 Bagsvaerd
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Allan Arp (Mr.)