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Development of novel treatment strategies based on knowledge of cellular dysfunction in diabetes

Objectif

A reduction in functional pancreatic beta cell mass is the key feature of type 1 and type 2 diabetes. Beta cell failure is exacerbated in the context of obesity and insulin resistance. Brown adipose tissue (BAT) is a highly metabolic organ, mediating energy dissipation and glucose disposal, thus contributing to maintain energy balance. BAT dysfunction contributes to obesity and impaired glucose metabolism, increasing functional demand on the beta cells. The cellular dysfunction of beta cells and BAT in diabetes is the fruit of defective signal transduction and organelle function, and the vulnerability to these molecular defects may be modulated by diabetes genes. To identify the crosstalk and pathways responsible for beta cell and BAT dysfunction and beta cell apoptosis in diabetes at its real level of complexity, this consortium will use cutting edge genetics, functional (epi)genomics, molecular biology and computational tools to reach an accurate organelle and cell diagnosis. This diagnosis will be used to define novel targets for intervention to prevent dysfunction and facilitate recovery of functionally impaired metabolic tissues. Some of these targets have already been identified by consortium members, including endoplasmic reticulum (ER) stress and mitochondrial dysfunction and apoptosis. Since many of these targets are related to dysfunction of specific organelles, we will focus on the novel concept of organelle therapy, aiming to preserve mitochondrial and ER function by the use of viral vectors and small molecule chemical probes. We will thus follow a two-pronged approach, namely a focused approach to restore known and specific cellular/organelle dysfunctions and a systems biology approach to identify novel targets for intervention. This, in combination with high throughput screening of large compound libraries, will translate discoveries into innovative therapeutic strategies that halt destruction and facilitate recovery of cell dysfunction in diabetes.

Appel à propositions

FP7-HEALTH-2011-two-stage
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Coordinateur

UNIVERSITE LIBRE DE BRUXELLES
Adresse
Avenue Franklin Roosevelt 50
1050 Bruxelles
Belgique
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 1 354 000
Contact administratif
Angelique Greindl (Ms.)

Participants (10)

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contribution de l’UE
€ 994 000
Adresse
Trinity Lane The Old Schools
CB2 1TN Cambridge
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Renata Schaeffer (Ms.)
UNIVERSITE DE LAUSANNE
Suisse
Contribution de l’UE
€ 497 000
Adresse
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Nicole Vouilloz (Ms.)
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
États-Unis
Contribution de l’UE
€ 450 000
Adresse
North Torrey Pines Road 10901
92037 1005 La Jolla Ca
Type d’activité
Research Organisations
Contact administratif
Kathlyn L. Huson (Ms.)
UNIVERSITAT DE BARCELONA
Espagne
Contribution de l’UE
€ 474 000
Adresse
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Xavier Gutiérrez (Mr.)
MAX IV Laboratory, Lund University
Suède
Contribution de l’UE
€ 485 000
Adresse
Paradisgatan 5C
22100 Lund
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Jacqueline Postma (Dr.)
TEKNOLOGIAN TUTKIMUSKESKUS VTT

Participation terminée

Finlande
Contribution de l’UE
€ 286 333,60
Adresse
Tekniikantie 4 A
02044 VTT Espoo
Type d’activité
Research Organisations
Contact administratif
Sinikka Soirinsuo (Ms.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Allemagne
Contribution de l’UE
€ 482 000
Adresse
Carl-neuberg-strasse 1
30625 Hannover
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Angela Steinhusen (Ms.)
DNA VISION SA
Belgique
Contribution de l’UE
€ 356 000
Adresse
Avenue G Lemaitre 25
6041 Gosselies
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Dimitri Lhoste (Mr.)
SIRION BIOTECH GMBH
Allemagne
Contribution de l’UE
€ 411 000
Adresse
Am Klopferspitz 19
82152 Planegg Martinsried
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Christian Thirion (Dr.)
NOVO NORDISK INVEST 4 A/S
Danemark
Contribution de l’UE
€ 209 666,40
Adresse
Novo Alle 1
2880 Bagsvaerd
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Allan Arp (Mr.)