Obiettivo The consortium aims to develop and produce an Anticalin, a member of a novel high-affinity scaffold derived from the lipocalin protein family. The Anticalin is specific for hepcidin which is a central regulator of iron homeostasis, and will be used to antagonize hepcidin for the treatment of “anemia of chronic disease” (ACD). Anticalins are genetically modified lipocalins that can target almost any desired molecule. Unlike Immunoglobulins, they can be produced at low cost in microbial expression systems, are expected to be non immunogenic and offer therapeutic advantages where antibody effector functions are not desired. ACD, the most frequent anemia in hospitalized patients, develops in subjects suffering from infections, inflammatory and auto-immune disease, cancer and chronic kidney disease. It is often successfully treated by administering Erythropoiesis-Stimulating Agents. However, a significant number of patients are hypo- or non-responsive to ESA. Anti-hepcidin therapies, alone or together with ESAs, may improve anemia and the patients’ erythropoietic response and enable the use of no or even much lower ESA doses, avoiding the potential detrimental effects of high doses of ESA. The Consortium has already generated proof-of-concept data in an animal model with early candidates. The project aims at identifying, validating, and developing a specific, high affinity drug candidate based on the lipocalin scaffold as promising alternatives to immunoglobulins and a therapeutic approach based on the neutralization of hepcidin. Animal models will be developed and utilized to characterize pharmacokinetic and pharmacodynamic relationships, optimize dosing, to determine safety, biomarker responses and potential synergy with ESA’s. Furthermore, production processes will be optimized leading to a scalable GMP process which provides material for preclinical and clinical studies to establish the safety, tolerability, and PK/PD of an Anticalin hepcidin blocker (Phase Ia/b). Campo scientifico scienze mediche e della salutemedicina di basefarmacologia e farmaciascoperta di farmaciscienze naturaliscienze biologichebiochimicabiomolecoleproteinescienze mediche e della salutemedicina di baseimmunologiamalattie autoimmuniscienze mediche e della salutemedicina clinicaematologiascienze mediche e della salutemedicina clinicanefrologiamalattie renali Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2011.1.4-3 - Development and production of new, high-affinity protein scaffolds for therapeutic use Invito a presentare proposte FP7-HEALTH-2011-two-stage Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore PIERIS PHARMACEUTICALS GMBH Indirizzo Lise-meitner-straße 30 85354 Freising Germania Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Rita Fischer (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Contributo UE € 2 164 000,00 Partecipanti (10) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto TECHNISCHE UNIVERSITAET MUENCHEN Germania Contributo UE € 261 600,00 Indirizzo Arcisstrasse 21 80333 Muenchen Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ulrike Ronchetti (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window MEDIZINISCHE UNIVERSITAT INNSBRUCK Austria Contributo UE € 416 200,00 Indirizzo Christoph probst platz 1 6020 Innsbruck Mostra sulla mappa Regione Westösterreich Tirol Innsbruck Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Guenter Weiss (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window STICHTING RADBOUD UNIVERSITEIT Paesi Bassi Contributo UE € 494 340,00 Indirizzo Houtlaan 4 6525 XZ Nijmegen Mostra sulla mappa Regione Oost-Nederland Gelderland Arnhem/Nijmegen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Maarten Van Langen (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window LABCORP EARLY DEVELOPMENT LABORATORIES LIMITED Regno Unito Contributo UE € 456 800,00 Indirizzo Otley road HG3 IPY Harrogate Mostra sulla mappa Regione Yorkshire and the Humber North Yorkshire North Yorkshire CC Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Carol Noble (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window ANTITOPE LIMITED Regno Unito Contributo UE € 263 040,00 Indirizzo Babraham research campus CB22 3AT Cambridge Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Frank Carr (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED Regno Unito Contributo UE € 1 109 963,50 Indirizzo Belasis avenue TS23 1LH Billingham Mostra sulla mappa Regione North East (England) Tees Valley and Durham Hartlepool and Stockton-on-Tees Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Lyons Mike (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window CORIOLIS PHARMASERVICE GMBH Partecipazione conclusa Germania Contributo UE € 92 734,16 Indirizzo Am klopferspitz 19 82152 Martinsried Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Thomas Wiggenhorn Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window FGK CLINICAL RESEARCH GMBH Germania Contributo UE € 271 200,00 Indirizzo Heimeranstrasse 35 80339 Munchen Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Ina Ott (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window CONSULTECH TECHNOLOGIEBERATUNG GMBH Germania Contributo UE € 309 800,00 Indirizzo Morgensternstrasse 24 12207 Berlin Mostra sulla mappa Regione Berlin Berlin Berlin Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Daniel Schubart (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window CORIOLIS PHARMA RESEARCH GMBH* Germania Contributo UE € 156 625,84 Indirizzo Am klopferspitz 19 82152 Martinsried Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Thomas Wiggenhorn Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window
