Objective Bacterial infection is the major cause of disability and death in children worldwide. We will use meningococcal disease (MD) as a model to understand genetic factors underlying susceptibility and severity of childhood bacterial infection which will then be applied to other childhood infections. We have established cohorts of patients with MD in Central and Southern Europe (CE,SE), UK and Africa as well as cohorts with other bacterial infections. We have established an inter-disciplinary team with expertise in Infectious Diseases, Immunogenetics, Bio-informatics, Microbiology, Public Health and Vaccinology including SME and industrial partners. We have already undertaken a genome wide study (GWAS) to identify genes causing susceptibility to meningococcal disease in a UK cohort. We identified complement factor H (fH) and fH-related (fHr) genes controlling MD susceptibility. This finding is fundamental to prevention as vaccines containing the MD fH receptor are undergoing trials. We will undertake GWAS on the CE, and SE MD cohorts, allowing meta analysis, and cross validation, and undertake GWAS on 2,500 Meningococcal Vaccine recipients. We will use next generation sequencing to identify the causal variants within the fH/fHr region and other regions implicated by pathway and severity analyses of the three MD GWAS and vaccine GWAS. We will match bacterial and host genetic variation and identify mechanisms of action of fH variants and other genes controlling susceptibility and severity using RNA expression, functional analyses and animal models. We will identify Mendelian defects and rare mutations as well as copy number variation and epi-genetic effects using next generation sequencing and RNA sequencing in “extreme phenotype” cohorts with MD , pneumococcal ,staphylococcal and salmonella disease. The study will identify mechanisms underlying susceptibility, provide new targets for treatment and prevention, and identify those at risk of disease or poor outcome. Fields of science medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesmicrobiologybacteriologymedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesgeneticsRNA Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.2.1.1-3 - Large-scale genomics approaches to identify host determinants of infectious diseases Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Address South kensington campus exhibition road SW7 2AZ London United Kingdom See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Scott Wheatley (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 2 838 599,00 Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE UNIVERSITY OF LIVERPOOL United Kingdom EU contribution € 391 679,00 Address Brownlow hill 765 foundation building L69 7ZX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Administrative Contact Enitan Carrol (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 738 802,00 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Stephen Conway (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 796 799,00 Address Meibergdreef 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Salena Voorneman Links Contact the organisation Opens in new window Website Opens in new window ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 417 962,40 Address Dr molewaterplein 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Jan A. Hazelzet (Dr.) Links Contact the organisation Opens in new window Website Opens in new window STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 548 293,00 Address Houtlaan 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Wim Van Oijen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window MEDIZINISCHE UNIVERSITAT GRAZ Austria EU contribution € 796 800,00 Address Neue stiftingtalstrasse 6 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Administrative Contact Werner Zenz (Prof.) Links Contact the organisation Opens in new window Website Opens in new window SERVIZO GALEGO DE SAUDE Spain EU contribution € 1 195 200,00 Address Edificio administrativo san lázaro 15703 Santiago de compostela See on map Region Noroeste Galicia A Coruña Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Federico Martinon-Torres (Dr.) Links Contact the organisation Opens in new window Website Opens in new window BIOMEDICAL SCIENCES INSTITUTES Limited by Guarantee Singapore EU contribution € 996 000,00 Address Biopolis way 20 138668 Singapore See on map Activity type Research Organisations Administrative Contact Martin Lloyd Hibberd (Dr.) Links Contact the organisation Opens in new window Website Opens in new window OXFORD GENE TECHNOLOGY (OPERATIONS) Ltd United Kingdom EU contribution € 1 092 070,00 Address Begbroke science park, sandy lane, yarnton OX5 PF Oxford See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact James Clough (Mr.) Links Contact the organisation Opens in new window Website Opens in new window MICROPATHOLOGY LIMITED United Kingdom EU contribution € 599 592,00 Address Sir william lyons road CV4 7EZ Coventry See on map Region West Midlands (England) West Midlands Coventry Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Colin Grahammedical Director Fink (Dr.) Links Contact the organisation Opens in new window Website Opens in new window MEDICAL RESEARCH COUNCIL United Kingdom EU contribution € 599 710,00 Address 20 park crescent W1B 1AL London See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Kalifa Bojang (Dr.) Links Contact the organisation Opens in new window Website Opens in new window GLAXOSMITHKLINE VACCINES SRL Italy EU contribution € 298 775,00 Address Via fiorentina 1 53100 Siena See on map Region Centro (IT) Toscana Siena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Francesco Gulli (Dr.) Links Contact the organisation Opens in new window Website Opens in new window IC CONSULTANTS LTD United Kingdom EU contribution € 597 745,00 Address Sherfield building, imperial college of science, technology and medicine SW7 2AZ London See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Kornelia Jumel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAET BERN Switzerland EU contribution € 0,00 Address Hochschulstrasse 6 3012 Bern See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne Activity type Higher or Secondary Education Establishments Administrative Contact Christoph Aebi (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY OF NEWCASTLE UPON TYNE United Kingdom EU contribution € 80 620,60 Address Kings gate NE1 7RU Newcastle upon tyne See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Administrative Contact Debra Mudditt (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window