Se ti disconnetti da Login UE, uscirai anche da tutti gli altri servizi che usano il tuo account Login UE. Utilizza il pulsante di disconnessione di CORDIS per rimanere connesso agli altri servizi.
Questa pagina sarà tradotta automaticamente dal servizio eTranslation della Commissione europea per facilitarne la comprensione. Leggi le condizioni d’uso.
Molecular Studies of Astrocyte Function in Health and Disease
Final Report Summary - ASTROFUNC (Molecular Studies of Astrocyte Function in Health and Disease)
Astrocytes are the most numerous cells in the mammalian central nervous system (CNS) – yet their exact role(s) in both the healthy and diseased brain remain unclear. In this project we took a ‘bottom-up’ approach, in which we identified key molecular pathways controlling astrocyte function. Using advanced genetic tools (developed during this project), we manipulated selected proteins and monitored their effects on astrocyte function in vivo, using sophisticated microscopy techniques. Being able to assess astrocyte function in the healthy brain provides us with a baseline to understand the changes in astrocytes that occur in neurodegenerative diseases (such as Alzheimer’s), potentially allowing the identification of novel, alternative therapeutic targets.