Final Report Summary - IMPLANT (Silicon transport proteins in biological nanoscience and synthetic biology)
This project required that we establish a series of new methods for characterising these proteins. These new methods were a key outcome from the work, since they provide an experimental platform that can be used in the future by ourselves and others. We used these methods to provide the first direct information on the activity of this protein family, and these results led to a new model for silicon transporter function. The immediate impact of this work lies mainly in generating new basic knowledge concerning an important but enigmatic biological process; and in developing new experimental methods so that these proteins can be more easily studied in the future. The recent discovery of silicon transporters in other organisms, and the widespread existence of similar proteins in many land plants, offers the chance to explore the mechanisms that are used for silicon transport across biology. The achievements and outcomes of this Starting Grant puts us in an excellent position to lead this effort.