Final Report Summary - WIRINGVISION (Wiring up visual circuits: Interplay between gene expression and spontaneous and experience-dependent activity)
For the second aim of the project we have generated a transgenic mouse line with an increased number of ipsilateral visual axons and we are currently analyzing whether these mice have the capacity of rewiring their thalamocortical projections, expand the binocular visual cortical region and improve binocular vision. If this is the case, these results would demonstrate that a single gene mutation during development could lead to the complete rewiring of a circuit and the emergence of a new sensory capacity.