Objective Late-onset Alzheimer’s disease (LOAD) is a neurodegenerative disorder that currently affects 2% of the population in industrialized countries; the risk of LOAD increases in individuals beyond the age of 70 and it is predicted that the incidence of LOAD will increase 4-fold within the next 50 years which may cause a great socioeconomic problem. Early diagnosis and evidence-based interventions that improve the condition of LOAD patients are not available. Numerous studies revealed that LOAD is an age-related multifactorial disease, which is evident on the protein level in hardly accessible cerebrospinal fluid by decreased beta amyloid and increased hyperphosphorylated tau protein.The Medical University of Vienna and the diagnostics company Randox have already characterised LOAD related proteins in blood platelets that reflect features of neurons. These proteins indicate multifactorial interactions in LOAD leading to our holistic approach. The present project, unlike others, will simultaneously determine (epi)genetic, protein-specific, and metabolic parameters of LOAD patients.On the genetic level LOAD is associated with Apolipoprotein E4 polymorphism. Decreased vitamin B12 and folate and increased homocysteine levels are metabolic dysfunctions that may be linked to epigenetic changes in methylation patterns of LOAD relevant genes.The University of Vienna will identify metabolic LOAD markers in blood. The MUW will perform complementary (epi)genetic and proteomic studies, and will generate algorithms for multi-arrays. Significant (epi)genetic aberrations in LOAD will be translated into assays of a DNA Chip at Randox. In addition, the SME Ledo and the Polish University Politechnika Lodzka join their expertise to develop a standardised ready-to-use platelet isolation column for platelet purification.Only this intensive transfer of knowledge will achieve combined analysis of these different types of LOAD biomarkers which should allow accurate diagnosis and offer approaches to targeted therapy. Fields of science medical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Call for proposal FP7-PEOPLE-2011-IAPP See other projects for this call Funding Scheme MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinator MEDIZINISCHE UNIVERSITAET WIEN Address Spitalgasse 23 1090 Wien Austria See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Michael Freissmuth (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all Randox Laboratories Ltd United Kingdom EU contribution € 354 518,00 Address Diamond road 55 BT29 4QY Crumlin See on map Region Northern Ireland Northern Ireland Antrim and Newtownabbey Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact John Lamont (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data OLBRZYMEK LESZEK TADEUSZ LEDO P.P.H.U. LESZEK OLBRZYMEK Poland EU contribution € 36 706,00 Address Ulica gliniana 19 91336 Lodz See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Sylwia Olbrzymek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data POLITECHNIKA LODZKA Poland EU contribution € 13 148,00 Address Ulica zeromskiego 116 90 924 Lodz See on map Region Makroregion centralny Łódzkie Miasto Łódź Activity type Higher or Secondary Education Establishments Administrative Contact Bogdan Walkowiak (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAT WIEN Austria EU contribution € 59 320,00 Address Universitatsring 1 1010 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Juergen Koenig (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
