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Design of Novel Portable-Sensors Based on Suspension Arrays Composed of Monoclonal Antibody and<br/>Bacteriophage Carrying Magnetically Loaded Nanoparticles and Surface Enhanced Raman Spectroscopy

Objectif

In this project, we aim to develop nanotechnology-based systems for detection of pathogenic bacteria in several aqueous media mainly in environmental water based on suspension arrays together with a portable custom-designed detection system. The six objectives (six work packages) are as follows: (i) Nanostructured sensors surfaces, in which electron-beam, photo-, soft and dip-pen lithographies will be applied in the fabrication of functionalized low-cost (disposable) SERS substrates, specially designed for simultaneus Raman and Fluorescence enhancement; (ii) nanosorbents and their mixtures as suspension arrays against the target bacteria for capturing units in which firstly magnetically loaded nanoparticles will be produced and labelled/barcoaded with fluorosence dies and/or quantum dots and then bacteriophages, monoclonal antibodies, and/or aptamers will be immobilized onto these nanoparticles as bioligands to recognize and capture the target bacteria specifically; their mixtures will form the suspension arrays; (iii) target bacteria and bacteriophages; the target bacteria (as water pollutants), are Escherichia coli, Enterococcus species and Bacteroides ovatus; bacteriophages which will recognize these bacteria will be selected/produced as bioligands; (iv) aptamers; they will be selected/modified/produced; (v) sensors/array systems; a portable “Raman Spectrometer/Fluorescence Detector System” will be designed/produced that will be used together with the nanostructured sensors platforms, and finally (vi) validation; the materials and systems developed will be validated. This is a multidisciplinary and technological project and therefore brings together experts from different disciplines both from academia and industry. Basicly, the knowledge that will be developed/ accumulated at lab scale during the project will be transfered to the industrial partners for prototype productions, and then these will bring back to the academical institutions for validation tests.

Appel à propositions

FP7-PEOPLE-2011-IAPP
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Coordinateur

HACETTEPE UNIVERSITESI
Contribution de l’UE
€ 243 328,80
Adresse
HACETTEPE UNIVERSITESI BEYTEPE KAMPUSU REKTORLUK BINASI
06800 Cankaya Ankara
Turquie

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Région
Batı Anadolu Ankara Ankara
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Erhan Biskin (Prof.)
Liens
Coût total
Aucune donnée

Participants (6)