Study of the Listeria monocytogenes gene expression profile in ready-to-eat foods of animal origin by the application of the omics and the bioinformatics/biostatistics disciplines

Informazioni relative al progetto

LISGENOMICS

ID dell’accordo di sovvenzione: 293406

Progetto concluso

Data di avvio 1 Dicembre 2011

Data di completamento 1 Maggio 2014

Finanziato da

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Costo totale € 50 000,00

Contributo UE € 50 000,00

Coordinato da

UNIVERSITA DEGLI STUDI DI TORINO
Italy

Obiettivo

Although the rate of food contamination with Listeria monocytogenes is low, the mortality rate that is caused by this microorganism is high,
and for this reason, it is placed on the top of the list of pathogens of concern for the public health and consequently for the food industry. L.
monocytogenes has emerged as a food-borne pathogen the last decades, due to changes in food processing, consumer habits and the
demand for minimally processed foods. The molecular mechanism of virulence has gained a lot of attention and many steps of this
complex process have been elucidated to various levels. All L. monocytogenes strains found in foods should be considered to be
pathogenic. However, the relative virulence of individual L. monocytogenes isolates can vary substantially. The genetic basis underlying
these virulence differences is not yet understood. Differences in gene content exist between strains of different serovars and origins.
Differences among strains could also be due to different gene expression/regulation of the core genes of the microorganism. The ability to
rapidly determine the pathogenic potential of L. monocytogenes strains is integral to the control and prevention campaign against
listeriosis. Throughout the years, different approaches have been employed to assess virulence: in vivo bioassays, in vitro cell assays and
targeting virulence-associated proteins and genes. However, these methods have disadvantages such as the need for laboratory animals
(bioassays) and the time constraints. Furthermore, targeting virulence genes gives only an indication of the virulence potential of strains.
Nowadays, powerful alternatives such as microarrays and reverse transcriptional quantitative polymerase chain reaction (RT-qPCR) are
available that can assist in the definition of the virulence potential of L. monocyotogenes strains by the means of modelling.

Campo scientifico

• medical and health sciences › health sciences › public health
• social sciences › sociology › demography › mortality
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › biological sciences › microbiology

Programma(i)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Argomento(i)

• FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants"

Invito a presentare proposte

FP7-PEOPLE-2011-CIG
Vedi altri progetti per questo bando

Meccanismo di finanziamento

MC-CIG - Support for training and career development of researcher (CIG)

Coordinatore

UNIVERSITA DEGLI STUDI DI TORINO

Contatto amministrativo

Luca Cocolin (Dr.)

• Contributo UE: € 50 000,00
• Indirizzo: VIA GIUSEPPE VERDI 8 ; 10124 Torino ; Italia
• Regione: Nord-Ovest › Piemonte › Torino
• Tipo di attività: Higher or Secondary Education Establishments
• Costo totale: Nessun dato