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Engineering Proteases

Ziel

Enzymes find manifold economical applications reflected by a rapidly growing multi-billion dollar market covering industrial sectors from textiles and detergents to pharmaceuticals and the food and feed market. In order to adapt nature's products to industrial processes, one of the challenging tasks of protein engineering is the development of enzymes with new or improved properties. In this context proteases are of outstanding interest.

Proteases are nowadays used as one of the main components of detergents and additionally have an enormous potential as highly target-specific pharmaceuticals. With their enzymatic turnover they can catalytically inactivate target proteins thereby acting efficiently in unrivalled low concentrations. c-LEcta has developed proprietary technologies to evolutionary develop and optimize properties of enzymes.

With its unrivalled screening technology allowing looking through enzyme libraries with complexities of up to 100 million variants, c-LEcta develops enzyme products to be used as biocatalysts in chemical synthesis and as tools in molecular biology research. The screening technology of c-LEcta will be adapted to the enzyme class of proteases allowing c-LEcta to address the above mentioned markets. c-LEcta will enter the enzyme engineering market for the development of improved proteases for the detergent market and will establish the requirements to address the challenge of evolving highly sequence specific proteases as pharmaceutical drug candidates.

Two experienced researcher from the protease field will be integrated into c-LEcta's lab staff for 2.5 years with the aim of establishing the adaptation of the technology and realizing the proof of principle for the technology application for at least two examples. These researchers will work closely together with the members of the c-LEcta staff, of which one will do training for three months in our partner organisation in Barcelona.

Wissenschaftliches Gebiet (EuroSciVoc)

Schlüsselbegriffe

Thema/Themen

Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-3
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

TOK - Marie Curie actions-Transfer of Knowledge

Koordinator

C-LECTA GMBH
EU-Beitrag
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