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Methods for Integrated analysis of Multiple Omics datasets

Objective

MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with novel findings so far. Support for methodological development is missing. The state-of-the-art methodology does not match by far the complexity of the biological problem. Complex data are being analysed in a rather simple way which misses the opportunity to uncover combinations of predictive profiles among the omics data.
The objectives of MIMOmics are: to develop a statistical framework of methods for all analysis steps needed for identifying and interpreting omics-based biomarkers; and to integrate data derived from multiple omics platforms across several study designs and populations. Specific steps include: experimental design; pipelines for data gathering; cleaning of noisy spectra; predictive modeling of biomarkers; meta analysis; and causality assessment. To enhance our understanding, systems approaches will be considered for pathways and structural modelling of biological networks. The major challenge in the joint analysis of omics datasets will be to develop methods that deal with the high dimensionality, noisy spectral data, heterogeneity, and structure of these datasets.
To perform these tasks successfully we bring together established EU academic and industrial researchers in metabolomics, glycomics, biostatistics, bioinformatics, scientific computing and epidemiology, with complementary expertise. A key feature of our project is the validation of novel methodology by performing a proof of principle (Metabolic Health) . Special effort will be made for rapid uptake of methods by communication with associated consortia and development of user-friendly software

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 614 094
Administrative Contact
Karin Wibier (Ms.)

Participants (14)

UNIVERSITEIT HASSELT
Belgium
EU contribution
€ 433 600
Address
Martelarenlaan 42
3500 Hasselt
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tomasz Burzykowski (Prof.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 227 447
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fiona Edler (Ms.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 217 000,40
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renata Schaeffer (Ms.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 376 756
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gastone Castellani (Prof.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 451 519
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Jürgen Ertel (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 259 400
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Maria Giovanna Torti (Ms.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finland
EU contribution
€ 208 200
Address
Mannerheimintie 166
00271 Helsinki
Activity type
Research Organisations
Administrative Contact
Sanna Leppämäki (Ms.)
PHARMATICS LIMITED
United Kingdom
EU contribution
€ 405 700
Address
Duddingston View 49
EH15 3LZ Edinburgh
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Felix Agakov (Dr.)
ACOUSTICVIEW LTD
Israel
EU contribution
€ 112 302
Address
Eliyahu Hakim Str 14 - Suite 32
69120 Tel Aviv
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nathan Intrator (Prof.)
GENOS DOO ZA VJESTACENJE I ANALIZU
Croatia
EU contribution
€ 289 350
Address
Vatrogasna 112
31000 Osijek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gordan Lauc (Prof.)
YURII AULCHENKO
Netherlands
EU contribution
€ 254 400
Address
Tweede Hunzestraat 9 A
3067 EV Rotterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Yury Aulchenko (Dr.)
BIOCOMPUTING PLATFORMS LTD OY
Finland
EU contribution
€ 344 640
Address
Innopoli 3 Vaisalantie 6
02130 Espoo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anita Eliasson (Mrs.)
GENEXPLAIN GMBH
Germany
EU contribution
€ 347 800
Address
Am Exer 19 B
38302 Wolfenbuttel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Holger Michael (Dr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 451 099,60
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claire Faichnie (Ms.)