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Methods for Integrated analysis of Multiple Omics datasets

Objetivo

MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with novel findings so far. Support for methodological development is missing. The state-of-the-art methodology does not match by far the complexity of the biological problem. Complex data are being analysed in a rather simple way which misses the opportunity to uncover combinations of predictive profiles among the omics data.
The objectives of MIMOmics are: to develop a statistical framework of methods for all analysis steps needed for identifying and interpreting omics-based biomarkers; and to integrate data derived from multiple omics platforms across several study designs and populations. Specific steps include: experimental design; pipelines for data gathering; cleaning of noisy spectra; predictive modeling of biomarkers; meta analysis; and causality assessment. To enhance our understanding, systems approaches will be considered for pathways and structural modelling of biological networks. The major challenge in the joint analysis of omics datasets will be to develop methods that deal with the high dimensionality, noisy spectral data, heterogeneity, and structure of these datasets.
To perform these tasks successfully we bring together established EU academic and industrial researchers in metabolomics, glycomics, biostatistics, bioinformatics, scientific computing and epidemiology, with complementary expertise. A key feature of our project is the validation of novel methodology by performing a proof of principle (Metabolic Health) . Special effort will be made for rapid uptake of methods by communication with associated consortia and development of user-friendly software

Ámbito científico

  • /ciencias naturales/informática y ciencias de la información/ciencias de la computación

Convocatoria de propuestas

FP7-HEALTH-2012-INNOVATION-1
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Régimen de financiación

CP-FP - Small or medium-scale focused research project

Coordinador

ACADEMISCH ZIEKENHUIS LEIDEN
Dirección
Albinusdreef 2
2333 ZA Leiden
Países Bajos
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 1 614 094
Contacto administrativo
Karin Wibier (Ms.)

Participantes (14)

UNIVERSITEIT HASSELT
Bélgica
Aportación de la UE
€ 433 600
Dirección
Martelarenlaan 42
3500 Hasselt
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Tomasz Burzykowski (Prof.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
Aportación de la UE
€ 227 447
Dirección
Old College, South Bridge
EH8 9YL Edinburgh
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Fiona Edler (Ms.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Aportación de la UE
€ 217 000,40
Dirección
Trinity Lane The Old Schools
CB2 1TN Cambridge
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Renata Schaeffer (Ms.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italia
Aportación de la UE
€ 376 756
Dirección
Via Zamboni 33
40126 Bologna
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Gastone Castellani (Prof.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Alemania
Aportación de la UE
€ 451 519
Dirección
Ingolstadter Landstrasse 1
85764 Neuherberg
Tipo de actividad
Research Organisations
Contacto administrativo
Jürgen Ertel (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italia
Aportación de la UE
€ 259 400
Dirección
Piazzale Aldo Moro 7
00185 Roma
Tipo de actividad
Research Organisations
Contacto administrativo
Maria Giovanna Torti (Ms.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finlandia
Aportación de la UE
€ 208 200
Dirección
Mannerheimintie 166
00271 Helsinki
Tipo de actividad
Research Organisations
Contacto administrativo
Sanna Leppämäki (Ms.)
PHARMATICS LIMITED
United Kingdom
Aportación de la UE
€ 405 700
Dirección
9 Little France Road, Edinburgh Bioquarter
EH16 4UX Edinburgh
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Felix Agakov (Dr.)
ACOUSTICVIEW LTD
Israel
Aportación de la UE
€ 112 302
Dirección
Eliyahu Hakim Str 14 - Suite 32
69120 Tel Aviv
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Nathan Intrator (Prof.)
GENOS DOO ZA VJESTACENJE I ANALIZU
Croacia
Aportación de la UE
€ 289 350
Dirección
Vatrogasna 112
31000 Osijek
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Gordan Lauc (Prof.)
YURII AULCHENKO
Países Bajos
Aportación de la UE
€ 254 400
Dirección
Tweede Hunzestraat 9 A
3067 EV Rotterdam
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Yury Aulchenko (Dr.)
BIOCOMPUTING PLATFORMS LTD OY
Finlandia
Aportación de la UE
€ 344 640
Dirección
Innopoli 3 Vaisalantie 6
02130 Espoo
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Anita Eliasson (Mrs.)
GENEXPLAIN GMBH
Alemania
Aportación de la UE
€ 347 800
Dirección
Am Exer 19 B
38302 Wolfenbuttel
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Holger Michael (Dr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
Aportación de la UE
€ 451 099,60
Dirección
Oxford Road
M13 9PL Manchester
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Claire Faichnie (Ms.)