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Methods for Integrated analysis of Multiple Omics datasets

Objectif

MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with novel findings so far. Support for methodological development is missing. The state-of-the-art methodology does not match by far the complexity of the biological problem. Complex data are being analysed in a rather simple way which misses the opportunity to uncover combinations of predictive profiles among the omics data.
The objectives of MIMOmics are: to develop a statistical framework of methods for all analysis steps needed for identifying and interpreting omics-based biomarkers; and to integrate data derived from multiple omics platforms across several study designs and populations. Specific steps include: experimental design; pipelines for data gathering; cleaning of noisy spectra; predictive modeling of biomarkers; meta analysis; and causality assessment. To enhance our understanding, systems approaches will be considered for pathways and structural modelling of biological networks. The major challenge in the joint analysis of omics datasets will be to develop methods that deal with the high dimensionality, noisy spectral data, heterogeneity, and structure of these datasets.
To perform these tasks successfully we bring together established EU academic and industrial researchers in metabolomics, glycomics, biostatistics, bioinformatics, scientific computing and epidemiology, with complementary expertise. A key feature of our project is the validation of novel methodology by performing a proof of principle (Metabolic Health) . Special effort will be made for rapid uptake of methods by communication with associated consortia and development of user-friendly software

Appel à propositions

FP7-HEALTH-2012-INNOVATION-1
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Coordinateur

ACADEMISCH ZIEKENHUIS LEIDEN
Adresse
Albinusdreef 2
2333 ZA Leiden
Pays-Bas

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Karin Wibier (Ms.)
Contribution de l’UE
€ 1 614 094

Participants (14)

UNIVERSITEIT HASSELT
Belgique
Contribution de l’UE
€ 433 600
Adresse
Martelarenlaan 42
3500 Hasselt

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Tomasz Burzykowski (Prof.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
Contribution de l’UE
€ 227 447
Adresse
Old College, South Bridge
EH8 9YL Edinburgh

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Fiona Edler (Ms.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contribution de l’UE
€ 217 000,40
Adresse
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Renata Schaeffer (Ms.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italie
Contribution de l’UE
€ 376 756
Adresse
Via Zamboni 33
40126 Bologna

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Gastone Castellani (Prof.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Allemagne
Contribution de l’UE
€ 451 519
Adresse
Ingolstadter Landstrasse 1
85764 Neuherberg

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Type d’activité
Research Organisations
Contact administratif
Jürgen Ertel (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italie
Contribution de l’UE
€ 259 400
Adresse
Piazzale Aldo Moro 7
00185 Roma

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Type d’activité
Research Organisations
Contact administratif
Maria Giovanna Torti (Ms.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finlande
Contribution de l’UE
€ 208 200
Adresse
Mannerheimintie 166
00271 Helsinki

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Type d’activité
Research Organisations
Contact administratif
Sanna Leppämäki (Ms.)
PHARMATICS LIMITED
United Kingdom
Contribution de l’UE
€ 405 700
Adresse
9 Little France Road, Edinburgh Bioquarter
EH16 4UX Edinburgh

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Felix Agakov (Dr.)
ACOUSTICVIEW LTD
Israël
Contribution de l’UE
€ 112 302
Adresse
Eliyahu Hakim Str 14 - Suite 32
69120 Tel Aviv

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Nathan Intrator (Prof.)
GENOS DOO ZA VJESTACENJE I ANALIZU
Croatie
Contribution de l’UE
€ 289 350
Adresse
Vatrogasna 112
31000 Osijek

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Gordan Lauc (Prof.)
YURII AULCHENKO
Pays-Bas
Contribution de l’UE
€ 254 400
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Yury Aulchenko (Dr.)
BIOCOMPUTING PLATFORMS LTD OY
Finlande
Contribution de l’UE
€ 344 640
Adresse
Innopoli 3 Vaisalantie 6
02130 Espoo

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Anita Eliasson (Mrs.)
GENEXPLAIN GMBH
Allemagne
Contribution de l’UE
€ 347 800
Adresse
Am Exer 19 B
38302 Wolfenbuttel

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Holger Michael (Dr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
Contribution de l’UE
€ 451 099,60
Adresse
Oxford Road
M13 9PL Manchester

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Claire Faichnie (Ms.)