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Methods for Integrated analysis of Multiple Omics datasets

Obiettivo

MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with novel findings so far. Support for methodological development is missing. The state-of-the-art methodology does not match by far the complexity of the biological problem. Complex data are being analysed in a rather simple way which misses the opportunity to uncover combinations of predictive profiles among the omics data.
The objectives of MIMOmics are: to develop a statistical framework of methods for all analysis steps needed for identifying and interpreting omics-based biomarkers; and to integrate data derived from multiple omics platforms across several study designs and populations. Specific steps include: experimental design; pipelines for data gathering; cleaning of noisy spectra; predictive modeling of biomarkers; meta analysis; and causality assessment. To enhance our understanding, systems approaches will be considered for pathways and structural modelling of biological networks. The major challenge in the joint analysis of omics datasets will be to develop methods that deal with the high dimensionality, noisy spectral data, heterogeneity, and structure of these datasets.
To perform these tasks successfully we bring together established EU academic and industrial researchers in metabolomics, glycomics, biostatistics, bioinformatics, scientific computing and epidemiology, with complementary expertise. A key feature of our project is the validation of novel methodology by performing a proof of principle (Metabolic Health) . Special effort will be made for rapid uptake of methods by communication with associated consortia and development of user-friendly software

Invito a presentare proposte

FP7-HEALTH-2012-INNOVATION-1
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Coordinatore

ACADEMISCH ZIEKENHUIS LEIDEN
Indirizzo
Albinusdreef 2
2333 ZA Leiden
Paesi Bassi
Tipo di attività
Higher or Secondary Education Establishments
Contributo UE
€ 1 614 094
Contatto amministrativo
Karin Wibier (Ms.)

Partecipanti (14)

UNIVERSITEIT HASSELT
Belgio
Contributo UE
€ 433 600
Indirizzo
Martelarenlaan 42
3500 Hasselt
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Tomasz Burzykowski (Prof.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
Contributo UE
€ 227 447
Indirizzo
Old College, South Bridge
EH8 9YL Edinburgh
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Fiona Edler (Ms.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contributo UE
€ 217 000,40
Indirizzo
Trinity Lane The Old Schools
CB2 1TN Cambridge
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Renata Schaeffer (Ms.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italia
Contributo UE
€ 376 756
Indirizzo
Via Zamboni 33
40126 Bologna
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Gastone Castellani (Prof.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germania
Contributo UE
€ 451 519
Indirizzo
Ingolstadter Landstrasse 1
85764 Neuherberg
Tipo di attività
Research Organisations
Contatto amministrativo
Jürgen Ertel (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italia
Contributo UE
€ 259 400
Indirizzo
Piazzale Aldo Moro 7
00185 Roma
Tipo di attività
Research Organisations
Contatto amministrativo
Maria Giovanna Torti (Ms.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finlandia
Contributo UE
€ 208 200
Indirizzo
Mannerheimintie 166
00271 Helsinki
Tipo di attività
Research Organisations
Contatto amministrativo
Sanna Leppämäki (Ms.)
PHARMATICS LIMITED
United Kingdom
Contributo UE
€ 405 700
Indirizzo
9 Little France Road, Edinburgh Bioquarter
EH16 4UX Edinburgh
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Felix Agakov (Dr.)
ACOUSTICVIEW LTD
Israele
Contributo UE
€ 112 302
Indirizzo
Eliyahu Hakim Str 14 - Suite 32
69120 Tel Aviv
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Nathan Intrator (Prof.)
GENOS DOO ZA VJESTACENJE I ANALIZU
Croazia
Contributo UE
€ 289 350
Indirizzo
Vatrogasna 112
31000 Osijek
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Gordan Lauc (Prof.)
YURII AULCHENKO
Paesi Bassi
Contributo UE
€ 254 400
Indirizzo
Tweede Hunzestraat 9 A
3067 EV Rotterdam
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Yury Aulchenko (Dr.)
BIOCOMPUTING PLATFORMS LTD OY
Finlandia
Contributo UE
€ 344 640
Indirizzo
Innopoli 3 Vaisalantie 6
02130 Espoo
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Anita Eliasson (Mrs.)
GENEXPLAIN GMBH
Germania
Contributo UE
€ 347 800
Indirizzo
Am Exer 19 B
38302 Wolfenbuttel
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Holger Michael (Dr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
Contributo UE
€ 451 099,60
Indirizzo
Oxford Road
M13 9PL Manchester
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Claire Faichnie (Ms.)